| Zugriffsnummer | 35136 |
| Dokumenttyp | Zeitschriftenartikel |
| Peer Review | mit Peer Review |
| Sprache | Englisch |
| Titel | Reference materials and representative test materials to develop nanoparticle characterization methods: the NanoChOp project case |
| Autor(in); Institution |
Roebben, Gert; Institute for Reference Materials and Measurements, Joint Research Centre, European Commission, Geel, BELGIUM
Kestens, Vikram; Institute for Reference Materials and Measurements, Joint Research Centre, European Commission, Geel, BELGIUM
Varga, Zoltan; Institute of Materials and Environmental Chemistry, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Budapest, HUNGARY
Charoud-Got, Jean; Institute for Reference Materials and Measurements, Joint Research Centre, European Commission, Geel, BELGIUM
Ramaye, Yannic; Institute for Reference Materials and Measurements, Joint Research Centre, European Commission, Geel, BELGIUM
Gollwitzer, Christian; 7.1, Radiometrie mit Synchrotronstrahlung, PTB-Berlin
Bartczak, Dorota; LGC Limited, Teddington, UK
Geißler, Daniel; Biophotonics Division 1.10, Federal Institute for Materials Research and Testing, Berlin, GERMANY
Noble, James; Analytical Sciences, National Physical Laboratory, Teddington, UK
Mazoua, Stephane; Institute for Reference Materials and Measurements, Joint Research Centre, European Commission, Geel, BELGIUM
Meeus, Nele; Institute for Reference Materials and Measurements, Joint Research Centre, European Commission, Geel, BELGIUM
Corbisier, Philippe; Institute for Reference Materials and Measurements, Joint Research Centre, European Commission, Geel, BELGIUM
Palmai, Marcell; Institute of Materials and Environmental Chemistry, Research Centrefor Natural Sciences, Hungarian Academy of Sciences, Budapest, HUNGARY
Mihály, Judith; Institute of Materials and Environmental Chemistry, Research Centrefor Natural Sciences, Hungarian Academy of Sciences, Budapest, HUNGARY
Krumrey, Michael; 7.1, Radiometrie mit Synchrotronstrahlung, PTB-Berlin
Davies, Julie; LGC Limited, Teddington, UK
Resch-Genger, Ute; Biophotonics Division 1.10, Federal Institute for Materials Research and Testing, Berlin, GERMANY
Kumarswami, Neelam; Analytical Sciences, National Physical Laboratory, Teddington, UK
Minelli, Caterina; Analytical Sciences, National Physical Laboratory, Teddington, UK
Sikora, Aneta; Analytical Sciences, National Physical Laboratory, Teddington, UK
Goenaga-Infante, Heidi; LGC Limited, Teddington, UK
|
| Quelle/Jahr | Frontiers in Chemistry: 3 (2015), 1 - 16 |
| ISSN | 2296-2646 |
| DOI | |
| Verlag | Lausanne: Frontiers Media |
| Freie Schlagworte | nanoparticle ; materials characterization ; reference material ; analytical quality assurance ; metrology |
| Zusammenfassung | This paper describes the production and characteristics of the nanoparticle tes tmaterials prepared for common use in the collaborative research project NanoChOp (Chemical and optical characterization of nanomaterials in biological systems), in casusu supensions of silica nanoparticles and CdSe/CdS ZnS quantum dots (QDs). This paper is the first to illustrate how to assess whether nanoparticle test materials meet the requirements of a “reference material” (ISOGuide30,2015) or rather those of the recently defined category of “representative test material (RTM)” (ISO/TS16195,2013). The NanoChOp test materials were investigated with small-angle X-ray scattering (SAXS), dynamic light scattering (DLS), and centrifugal liquid sedimentation (CLS) to establish whether they complied with the required monomodal particle size distribution. The presence of impurities, aggregates, agglomerates, and viable microorganisms in the suspensions was investigated with DLS, CLS, optical and electron microscopy and via plating on nutrient agar. Suitability of surface functionalization was investigated with attenuated total reflection Fourier transform infrared spectrometry (ATR-FTIR) and via the capacity of the nanoparticles to be fluorescently labeled or to bind antibodies. Between-unit homogeneity and stability were investigated in terms of particle size and zeta potential. This paper shows that only based on the outcome of a detailed characterization process one can raise the status of a test material to RTM or reference material, and how this status depends on its intended use. |
| Kostenfreier Zugang | Open Access Gold |
| Rechteinformation | CC BY 4.0 ; Creative Commons Attribution 4.0 License |
Zitierung
Roebben, G., Kestens, V., Varga, Z., Charoud-Got, J., Ramaye, Y., Gollwitzer, C., Bartczak, D., Geißler, D., Noble, J., Mazoua, S., Meeus, N., Corbisier, P., Palmai, M., Mihály, J., Krumrey, M., Davies, J., Resch-Genger, U., Kumarswami, N., Minelli, C., Sikora, A., & Goenaga-Infante, H. (2015). Reference materials and representative test materials to develop nanoparticle characterization methods: the NanoChOp project case. Frontiers in Chemistry, 3, 1–16. https://doi.org/10.3389/fchem.2015.00056