| Zugriffsnummer | 34810 |
| Dokumenttyp | Zeitschriftenartikel |
| Peer Review | mit Peer Review |
| Sprache | Englisch |
| Titel | Thermal magnetic resonance: physics considerations and electromagnetic field simulations up to 23.5 Tesla (1GHz) |
| Autor(in); Institution |
Winter, L.; Berlin Ultrahigh Field Facility (B.U.F.F.), Max-Delbrück Center for Molecular Medicine, Berlin, GERMANY
Oezerdem, C.; Berlin Ultrahigh Field Facility (B.U.F.F.), Max-Delbrück Center for Molecular Medicine, Berlin, GERMANY
Hoffmann, Werner; 8.1, Medizinische Messtechnik, PTB-Berlin
Tessa, van de Lindt; Berlin Ultrahigh Field Facility (B.U.F.F.), Max-Delbrück Center for Molecular Medicine, Berlin, GERMANY
Periquito, J.; Berlin Ultrahigh Field Facility (B.U.F.F.), Max-Delbrück Center for Molecular Medicine, Berlin, GERMANY
Ji, Y.; Berlin Ultrahigh Field Facility (B.U.F.F.), Max-Delbrück Center for Molecular Medicine, Berlin, GERMANY
Ghadjar, P.; Department of Radiation Oncology, Charité Universitätsmedizin Berlin, Berlin, GERMANY
Budach, V.; Department of Radiation Oncology, Charité Universitätsmedizin Berlin, Berlin, GERMANY
Wust, P.; Department of Radiation Oncology, Charité Universitätsmedizin Berlin, Berlin, GERMANY
Niendorf, Th.; Experimental and Clinical Research Center (ECRC), a joint cooperation between the Charité Medical Faculty and the Max-Delbrueck Center for Molecular Medicine, Berlin, GERMANY; MRI.TOOLS GmbH, Berlin, GERMANY
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| Quelle/Jahr | Radiation Oncology: 10 (2015), 201, 12 S. |
| ISSN | 1748-717X |
| DOI | |
| Verlag | London: BioMed Central |
| Freie Schlagworte | thermal magnetic resonance ; magnetic resonance imaging ; hyperthermia ; radio frequency ; RF coil technology ; gliablastoma multiforme ; radiation oncology ; thermometry ; targeted drug delivery ; thermal therapies |
| Zusammenfassung | Background: Glioblastoma multiforme is the most common and most aggressive malign brain tumor. The 5-year survival rate after tumor resection and adjuvant chemoradiation is only 10%, with almost all recurrences occurring in the initially treated site. Attempts to improve local control using a higher radiation dose were not successful so that alternative additive treatments are urgently needed. Given the strong rationale for hyperthermia as part of a multimodal treatment for patients with glioblastoma, non-invasive radio frequency (RF) hyperthermia might significantly improve treatment results. Methods: A non-invasive applicator was constructed utilizing the magnetic resonance (MR) spin excitation frequency for controlled RF hyperthermia and MR imaging in an integrated system, which we refer to as thermal MR. Applicator designs at RF frequencies 300MHz, 500MHz and 1GHz were investigated and examined for absolute applicable thermal dose and temperature hotspot size. Electromagnetic field (EMF) and temperature simulations were performed in human voxel models. RF heating experiments were conducted at 300MHz and 500MHz to characterize the applicator performance and validate the simulations. Results The feasibility of thermal MR was demonstrated at 7.0T. The temperature could be increased by ˜11°C in 3min in the center of a head sized phantom. Modification of the RF phases allowed steering of a temperature hotspot to a deliberately selected location. RF heating was monitored using the integrated system for MR thermometry and high spatial resolution MRI. EMF and thermal simulations demonstrated that local RF hyperthermia using the integrated system is feasible to reach a maximum temperature in the center of the human brain of 46.8°C after 3min of RF heating while surface temperatures stayed below 41°C. Using higher RF frequencies reduces the size of the temperature hotspot significantly. Conclusion The opportunities and capabilities of thermal magnetic resonance for RF hyperthermia interventions of intracranial lesions are intriguing. Employing such systems as an alternative additive treatment for glioblastoma multiforme might be able to improve local control by "fighting fire with fire". Interventions are not limited to the human brain and might include temperature driven targeted drug and MR contrast agent delivery and help to understand temperature dependent bio- and physiological processes in-vivo. |
| Kostenfreier Zugang | Open Access Gold |
| Rechteinformation | CC BY 4.0 ; Creative Commons Attribution 4.0 License |
Zitierung
Winter, L., Oezerdem, C., Hoffmann, W., Tessa, V. D. L., Periquito, J., Ji, Y., Ghadjar, P., Budach, V., Wust, P., & Niendorf, T. (2015). Thermal magnetic resonance: physics considerations and electromagnetic field simulations up to 23.5 Tesla (1GHz). Radiation Oncology, 10(201), 12 S. https://doi.org/10.1186/s13014-015-0510-9