| Zugriffsnummer | 34067 |
| Dokumenttyp | Zeitschriftenartikel |
| Peer Review | unbekannt |
| Sprache | Englisch |
| Titel | From mother to child: orbitofrontal cortex gyrification and changes of drinking behaviour during adolescence. |
| Autor(in); Institution |
Kühn, S.; Max Planck Institute for Human Development, GERMANY; University Clinic Hamburg-Eppendorf, Clinic and Policlinic for Psychiatry and Psychotherapy, GERMANY
Witt, C.; Max Planck Institute for Human Development, GERMANY
Banaschewski, T.; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, GERMANY; Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, GERMANY
Barbot, A.; Neurospin, Commissariat à l'Energie Atomique, FRANCE
Barker, GJ.; King's College London, Institute of Psychiatry, UK
Büchel, C.; University Medical Centre Hamburg-Eppendorf, Hamburg, GERMANY
Conrod, PJ.; King's College London, Institute of Psychiatry, UK
Garavan, H.; Institute of Neuroscience, School of Medicine, Trinity College Dublin, Dublin, IRELAND; Department of Psychiatry and Psychology, University of Vermont, Burlington, VT, USA
Ittermann, Bernd; 8.1, Medizinische Messtechnik, PTB-Berlin
Mann, K.; Institute of Neuroscience, Trinity College Dublin, Dublin, IRELAND; Departments of Psychiatry and Psychology, University of Vermont, Burlington, Vermont, USA
Martinot, JL.; Institut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 ‘Imaging and Psychiatry’, University Paris Sud, France; AP-HP Department of Adolescent Psychopathology and Medicine, Maison de Solenn, University Paris Descartes, FRANCE
the IMAGEN Consortium,
et al.,
|
| Quelle/Jahr | Addiction Biology: 21 (2016), 3, 700 - 708 |
| ISSN | 1355-6215 (PRINT) ; 1369-1600 (ONLINE) |
| DOI | |
| Verlag | Hoboken, NJ [u.a.]: Wiley-Blackwell |
| Freie Schlagworte | Adolescence ; alcohol use ; dependence ; gyrification ; maternal drinking |
| Zusammenfassung | Adolescence is a common time for initiation of alcohol use and alcohol use disorders. Importantly, the neuro-anatomical foundation for later alcohol-related problems may already manifest pre-natally, particularly due to smoking and alcohol consumption during pregnancy. In this context, cortical gyrification is an interesting marker of neuronal development but has not been investigated as a risk factor for adolescent alcohol use. On magnetic resonance imaging scans of 595 14-year-old adolescents from the IMAGEN sample, we computed whole-brain mean curvature indices to predict change in alcohol-related problems over the following 2 years. Change of alcohol use-related problems was significantly predicted from mean curvature in left orbitofrontal cortex (OFC). Less gyrification of OFC was associated with an increase in alcohol use-related problems over the next 2 years. Moreover, lower gyrification in left OFC was related to pre-natal alcohol exposure, whereas maternal smoking during pregnancy had no effect. Current alcohol use-related problems of the biological mother had no effect on offsprings' OFC gyrification or drinking behaviour. The data support the idea that alcohol consumption during pregnancy mediates the development of neuro-anatomical phenotypes, which in turn constitute a risk factor for increasing problems due to alcohol consumption in a vulnerable stage of life. Maternal smoking during pregnancy or current maternal alcohol/nicotine consumption had no significant effect. The OFC mediates behaviours known to be disturbed in addiction, namely impulse control and reward processing. The results stress the importance of pre-natal alcohol exposure for later increases in alcohol use-related problems, mediated by structural brain characteristics. |
| Weitere Informationen | 20 Authors, not all individual authors are listed ; 20 Institutions, not all institutions are listed |
Zitierung
Kühn, S., Witt, C., Banaschewski, T., Barbot, A., Barker, G., Büchel, C., Conrod, P., Garavan, H., Ittermann, B., Mann, K., Martinot, J., the IMAGEN Consortium, & et al. (2016). From mother to child: orbitofrontal cortex gyrification and changes of drinking behaviour during adolescence. Addiction Biology, 21(3), 700–708. https://doi.org/10.1111/adb.12240