| Zugriffsnummer | 33672 |
| Dokumenttyp | Zeitschriftenartikel |
| Peer Review | unbekannt |
| Sprache | Englisch |
| Titel | Neurotransmitter changes during interference task in anterior cingulate cortex: evidence from fMRI guided functional MRS at 3T |
| Autor(in); Institution |
Kühn, S.; Max Planck Institute for Human Development, Center for Lifespan Psychology, Berlin, GERMANY
Schubert, Florian; 8.1, Medizinische Messtechnik, PTB-Berlin
Mekle, Ralf; 8.1, Medizinische Messtechnik, PTB-Berlin
Wenger, E.; Max Planck Institute for Human Development, Center for Lifespan Psychology, Berlin, GERMANY
Ittermann, Bernd; 8.1, Medizinische Messtechnik, PTB-Berlin
Lindenberger, U.; Max Planck Institute for Human Development, Center for Lifespan Psychology, Berlin, GERMANY
Gallinat, J.; Charité University Medicine, St. Hedwig-Krankenhaus, Clinic for Psychiatry and Psychotherapy, Berlin, GERMANY
|
| Quelle/Jahr | Brain Structure and Function: 221 (2016), 5, 2541 - 2551 |
| ISSN | 1863-2653 (PRINT) ; 1863-2661 (ONLINE) |
| DOI | |
| Verlag | Berlin [u.a.]: Springer |
| Freie Schlagworte | Spectroscopy ; GABA glutamate ; MRS ; fMRI ; Stroop |
| Zusammenfassung | Neural activity as indirectly observed in blood oxygenation level-dependent (BOLD) response is thought to reflect changes in neurotransmitter flux. In this study, we used fMRI-guided functional magnetic resonance spectroscopy (MRS) to measure metabolite/BOLD associations during a cognitive task at 3 T. GABA and glutamate concentration in anterior cingulate cortex (ACC) were determined by means of MRS using the SPECIAL pulse sequence before, during and after the performance of a manual Stroop task. MRS voxel positions were centred around individuals' BOLD activity during Stroop performance. Levels of GABA and glutamate showed inverted U-shape patterns across measurement time points (before, during, and after task), glutamine increased linearly and total creatine did not change. The GABA increase during task performance was associated with ACC BOLD signal changes in both congruent and incongruent Stroop conditions. Using an fMRI-guided MRS approach, an association between induced inhibitory neurotransmitter increase and BOLD changes was observed. The proposed procedure might allow the in vivo investigation of normal and dysfunctional associations between neurotransmitters and BOLD signal crucial for cerebral functioning. |
Zitierung
Kühn, S., Schubert, F., Mekle, R., Wenger, E., Ittermann, B., Lindenberger, U., & Gallinat, J. (2016). Neurotransmitter changes during interference task in anterior cingulate cortex: evidence from fMRI guided functional MRS at 3T. Brain Structure and Function, 221(5), 2541–2551. https://doi.org/10.1007/s00429-015-1057-0