| Zugriffsnummer | 33593 |
| Dokumenttyp | Buchartikel |
| Sprache | Englisch |
| Titel | Time-domain diffuse optical imaging of tissue by non-contact scanning |
| Autor(in); Institution |
Wabnitz, Heidrun; 8.3, Biomedizinische Optik, PTB-Berlin
Mazurenka, Mikhail; 8.3, Biomedizinische Optik, PTB-Berlin
Di Sieno, Laura; Dipartimento di Fisica, Politecnico di Milano, Milano, ITALY
Boso, Gianluca; Dipartimento di Elettronica, Informazione e Bioingegneria, Politecnico di Milano, Milano, ITALY
Becker, Wolfgang; Becker & Hickl GmbH, Berlin, GERMANY
Fuchs, Katja; 8.3, Biomedizinische Optik, PTB-Berlin
Contini, Davide; Dipartimento di Fisica, Politecnico di Milano, Milano, ITALY
Dalla Mora, Alberto; Dipartimento di Fisica, Politecnico di Milano, Milano, ITALY
Tosi, Alberto; Dipartimento di Elettronica, Informazione e Bioingegneria, Politecnico di Milano, Milano, ITALY
Macdonald, Rainer; 8.3, Biomedizinische Optik, PTB-Berlin
Pifferi, Antonio; Dipartimento di Fisica, Politecnico di Milano, Milano, ITALY
|
| Quelle/Jahr | Advanced time-correlated single photon counting applications:(2015), 561 - 585 |
| Schriftenreihe | Springer Series in Chemical Physics: 111 |
| Herausgeber(in) |
Becker, Wolfgang; Becker & Hickl GmbH, Berlin, GERMANY
|
| ISBN | 978-3-319-14928-8 (print) ; 978-3-319-14929-5 (online) |
| DOI | |
| Verlag | Cham (u.a.): Springer |
| Freie Schlagworte | time-resolved diffuse optical imaging ; non-contact imaging ; scanning imaging ; fast-gated single-photon avalanche diode ; time-correlated single photon counting ; in-vivo measurements ; functional near-infrared spectroscopy ; fNIRS ; brain activation ; haemoglobin concentration changes |
| Zusammenfassung | We present the concept, design and first in vivo tests of a novel non-contact scanning imaging system for time-domain near-infrared spectroscopy of tissues. Employing a supercontinuum laser in combination with an acousto-optic tunable filter as light source, the tissue was scanned by a galvanometer scanner from a distance of more than 10 cm. The distance between the illumination spot (source) and the detection spot from which the diffusely remitted photons were collected was small (few mm) and kept fixed during the scan. A fast-gated single-photon avalanche diode was employed to eliminate the intense early part of the diffusely remitted signal and to detect late photons only. Polarization-selective detection was additionally applied to suppress specular reflections from the object. An array of gated time-of-flight distributions of photons was recorded by imaging TCSPC synchronized with the movement of the galvanometer scanner. A tissue area of several cm2 was scanned with 32×32 pixels within a frame rate of 1 s-1 . The wavelength was switched line by line between two bands centred at 760 nm and 860 nm. Concentration changes of oxy- and deoxyhaemoglobin were derived from changes in photon counts in a selected time window of the gated distributions at the two wavelengths. First in vivo tests included the recording of haemodynamics during arm occlusion as well as brain activation tasks. These tests demonstrated the successful non-contact imaging of haemoglobin concentration changes in deeper tissues. Additional applications seem feasible by increasing the spectral information content of the non-contact scanning approach. To this end we implemented and tested the non-contact scanning in combination with eight-wavelength multiplexing. |
Zitierung
Wabnitz, H., Mazurenka, M., Di Sieno, L., Boso, G., Becker, W., Fuchs, K., Contini, D., Dalla Mora, A., Tosi, A., Macdonald, R., & Pifferi, A. (2015). Time-domain diffuse optical imaging of tissue by non-contact scanning. In W. Becker (Ed.), Advanced time-correlated single photon counting applications (pp. 561–585). Cham (u.a.): Springer. https://doi.org/10.1007/978-3-319-14929-5_18