| Zugriffsnummer | 33401 |
| Dokumenttyp | Zeitschriftenartikel |
| Sprache | Englisch |
| Titel | Ultra-low-noise EEG/MEG Systems enable bimodal non-invasive detection of spike-like human somatosensory evoked responses at 1 kHz |
| Autor(in); Institution |
Fedele, Tommaso; 8.2, Biosignale, PTB-Berlin; Neurophysics Group, Department of Neurology, Campus Benjamin Franklin, Charité - University Medicine Berlin, Berlin, GERMANY
Scheer, Hans-Jürgen; 8.2, Biosignale, PTB-Berlin
Burghoff, Martin; 8.2, Biosignale, PTB-Berlin
Curio, G.; Neurophysics Group, Department of Neurology, Campus Benjamin Franklin, Charité - University Medicine Berlin, Berlin, GERMANY
Körber, Rainer; 8.2, Biosignale, PTB-Berlin; Magnicon GmbH, Berlin, GERMANY
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| Quelle/Jahr | Physiological Measurement: 36 (2015), 357 - 368 |
| ISSN | 0967-3334 (PRINT) ; 1361-6579 (ONLINE) |
| DOI | |
| Verlag | UK: IOP |
| Freie Schlagworte | low noise MEG ; low noise EEG ; high frequency somatosensory ; evoked potential |
| Zusammenfassung | Non-invasive EEG detection of very high frequency somatosensory evoked potentials featuring frequencies up to and above 1 kHz has been recently reported. Here, we establish the detectability of such components by combined low-noise EEG/MEG. We recorded SEP/SEF simultaneously using median nerve stimulation in five healthy human subjects inside an electromagnetically shielded room, combining a low-noise EEG custom-made amplifier (4.7 nV/√Hz) and a custom-made single-channel low-noise MEG (0.5 fT/√Hz @ 1 kHz). Both, low-noise EEG and MEG revealed three spectrally distinct and temporally overlapping evoked components: N20 (<100 Hz), sigma-burst (450–750 Hz), and kappa-burst (850–1200 Hz). The two recording modalities showed similar relative scaling of signal amplitude in all three frequencies domains (EEG [10 nV] ≅ MEG [1 fT]). Pronounced waveform (peak-by-peak) overlap of EEG and MEG signals is observed in the sigma band, whereas in the kappa band overlap was only partial. A decreasing signal-to-noise ratio (SNR; calculated for n = 12.000 averages) from sigma to kappa components characterizes both, electric and magnetic field recordings: Sigma-band SNR was 12.9 ± 5.5/19.8 ± 12.6 for EEG/MEG, and kappa-band SNR at 3.77 ± 0.8/4.5 ± 2.9. High-frequency performance of a tailor-made MEG matches closely with simultaneously recorded low-noise EEG for the non-invasive detection of somatosensory evoked activity at and above 1 kHz. Thus, future multi-channel dual-mode low-noise technology could offer complementary views for source reconstruction of the neural generators underlying such high-frequency responses, and render neural high-frequency processes related to multi-unit spike discharges accessible in non-invasive recordings. |
Zitierung
Fedele, T., Scheer, H.-J., Burghoff, M., Curio, G., & Körber, R. (2015). Ultra-low-noise EEG/MEG Systems enable bimodal non-invasive detection of spike-like human somatosensory evoked responses at 1 kHz. Physiological Measurement, 36, 357–368. http://doi.org/10.1088/0967-3334/36/2/357