| Zugriffsnummer | 33157 |
| Dokumenttyp | Konferenzartikel in Zeitschrift |
| Peer Review | unbekannt |
| Sprache | Englisch |
| Titel | Hydrodynamic and magnetic fractionation of superparamagnetic nanoparticles for magnetic particle imaging |
| Autor(in); Institution |
Löwa, Norbert; 8.2, Biosignale, PTB-Berlin
Knappe, Patrick; BAM, Berlin, GERMANY
Wiekhorst, Frank; 8.2, Biosignale, PTB-Berlin
Eberbeck, Dietmar; 8.2, Biosignale, PTB-Berlin
Thünemann, A.; BAM, Berlin, GERMANY
Trahms, Lutz; 8.2, Biosignale, PTB-Berlin
|
| Quelle/Jahr | Special Issue: 10th International Conference on the Scientific and Clinical Applications of Magnetic Carriers 10-14 June, 2014, Dresden, Germany. Journal of Magnetism and Magnetic Materials: 380 (2015), 266 - 270 |
| ISSN | 0304-8853 (PRINT) |
| DOI | |
| Verlag | NorthHoll: Elsevier |
| Konferenzangaben | 10th International Conference on the Scientific and Clinical Applications of Magnetic Carriers 2014, Dresden, 10-14, June, 2014, GERMANY |
| Freie Schlagworte | superparamagnetic nanoparticles ; Asymmetric flow field-flow fractionation ; Magnetic particle spectroscopy ; Magnetorelaxometry ; Magnetic separation ; Magnetic Particle imaging ; Resovist® |
| Zusammenfassung | Resovist® originally developed as a clinical liver contrast agent for Magnetic Resonance Imaging exhibits also an outstanding performance as a tracer in Magnetic Particle Imaging (MPI). In order to study the physical mechanism of the high MPI performance of Resovist®, we applied asymmetric flow field-flow fractionation (A4F) and static magnetic fractionation (SMF) to separate Resovist® into a set of fractions with defined size classes. As A4F based on an elution method separates MNP according to their hydrodynamic size, SMF fractionates a particle distribution by its magnetic moment. The obtained fractions of both separation techniques were then magnetically characterized by magnetorelaxometry measurements to extract the corresponding effective magnetic anisotropy and hydrodynamic size distribution parameters. Additionally, the MPI performance of each fraction was assessed using magnetic particle spectroscopy. With both separation techniques fractions (normalized to their iron amount) an MPI signal gain of a factor of two could be obtained, even though the distribution of effective anisotropy and hydrodynamic size were significantly different. Relating these findings to the results from magnetic characterization allows for a better understanding of the underlying mechanisms of MPI performance of Resovist®. This knowledge may help to improve the design of novel MPI tracers and development of separation methods. |
Zitierung
Löwa, N., Knappe, P., Wiekhorst, F., Eberbeck, D., Thünemann, A., & Trahms, L. (2015). Hydrodynamic and magnetic fractionation of superparamagnetic nanoparticles for magnetic particle imaging. Journal of Magnetism and Magnetic Materials, 380, 266–270. http://doi.org/10.1016/j.jmmm.2014.08.057