| Zugriffsnummer | 33004 |
| Dokumenttyp | Zeitschriftenartikel |
| Peer Review | mit Peer Review |
| Sprache | Englisch |
| Titel | Future development of biologically relevant dosimetry |
| Autor(in); Institution |
Palmans, Hugo; National Physical Laboratory (NPL), Acoustics and Ionising Radiation Division, Teddington, UK; Medical Physics, EBG MedAustron GmbH, Wiener Neustadt, AUSTRIA
Rabus, Hans; 6.6, Grundlagen der Dosimetrie, PTB-Braunschweig
Belchior, Anna; Associacao do Instituto Superior Técnico para a Investigação e Desenvolvimento (IST-ID), Lisboa, PORTUGAL
Bug, Marion U.; 6.6, Grundlagen der Dosimetrie, PTB-Braunschweig
Galer, Sebastian; National Physical Laboratory (NPL), Acoustics and Ionising Radiation Division, Teddington, UK
Giesen, Ulrich; 6.4, Ionen- und Neutronenstrahlung, PTB-Braunschweig
Gonon, Géraldine; Institut de Radioprotection et de Sûreté Nucléaire (IRSN), Fontenay-aux-Roses, FRANCE
Gruel, Gaetan; Institut de Radioprotection et de Sûreté Nucléaire (IRSN), Fontenay-aux-Roses, FRANCE
Hilgers, Gerhard; 6.6, Grundlagen der Dosimetrie, PTB-Braunschweig
Moro, Davide; Laboratori Nazionale di Legnaro, Istituto Nazionale di Fisica Nucleare, Padova, ITALY
Nettelbeck, Heidi; 6.6, Grundlagen der Dosimetrie, PTB-Braunschweig
Pinto, Massimo; Centro Ricerche Casaccia, Istituto Nazionale di Metrologia delle Radiazioni Ionizzanti ENEA-INMRI, Rome, ITALY
Pola, Andrea; Politecnico di Milano, Department of Energy, Milano, ITALY
Pszona, Stanislaw; Narodowe Centrum Badán Jądrowych, Otwock-Swierk, POLAND
Schettino, Guiseppe; National Physical Laboratory (NPL), Acoustics and Ionising Radiation Division, Teddington, UK
Sharpe, Peter; National Physical Laboratory (NPL), Acoustics and Ionising Radiation Division, Teddington, UK
Teles, Pedro; Instituto Tecnológico e Nuclear, Instituto Superior Técnico, Sacavém, PORTUGAL
Villagrasa, Carmen; Institut de Radioprotection et de Sûreté Nucléaire (IRSN), Fontenay-aux-Roses, FRANCE
Wilkens, Jan J.; Technische Universität München, Klinikum rechts der Isar, Department of Radiation Oncology, Munich, GERMANY
|
| Quelle/Jahr | British Journal of Radiology: 88 (2015), 1045, 1 - 19 |
| Artikelnummer | 20140392 |
| ISSN | 0007-1285 (PRINT) ; 1748-880X (ONLINE) |
| DOI | |
| Verlag | London: British Institute of Radiology |
| Freie Schlagworte | radiation quantities ; biologically relevant dosimetry ; microbeam ; nanodosimetry ; microdosimetry ; reactive species ; BioQuaRT |
| Zusammenfassung | Proton and ion beams are radiotherapy modalities of increasing importance and interest. Because of the different biological dose response of these radiations as compared to high-energy photon beams, the current approach of treatment prescription is based on the product of the absorbed dose to water and a biological weighting factor, but this is found to be insufficient for providing a generic method to quantify the biological outcome of radiation. It is therefore suggested to define new dosimetric quantities which allow a transparent separation of the physical processes from the biological ones. Given the complexity of the initiation and occurrence of biological processes on various time and length scales, and given that neither microdosimetry nor nanodosimetry on their own can fully describe the biological effects as function of the distribution of energy deposition or ionisation, a multi-scale approach is needed to lay the foundation for the aforementioned new physical quantities relating track structure to relative biological effectiveness in proton and ion beam therapy. This paper reviews the state of the art of microdosimetry, nanodosimetry, track structure simulations, quantification of reactive species, reference radiobiological data, cross section data and multi-scale models of biological response in the context of realising the new quantities. It also introduces the European metrology project, BioQuaRT, which aims to investigate the feasibility of establishing a multi-scale model as the basis of the new quantities. |
| Kostenfreier Zugang | Open Access Hybrid |
| Rechteinformation | CC BY 4.0 ; Creative Commons Attribution 4.0 License |
Zitierung
Palmans, H., Rabus, H., Belchior, A., Bug, M. U., Galer, S., Giesen, U., Gonon, G., Gruel, G., Hilgers, G., Moro, D., Nettelbeck, H., Pinto, M., Pola, A., Pszona, S., Schettino, G., Sharpe, P., Teles, P., Villagrasa, C., & Wilkens, J. J. (2015). Future development of biologically relevant dosimetry. British Journal of Radiology, 88(1045), 1–19. https://doi.org/10.1259/bjr.20140392