| Zugriffsnummer | 32809 |
| Dokumenttyp | Zeitschriftenartikel |
| Peer Review | mit Peer Review |
| Sprache | Englisch |
| Titel | Detailing renal hemodynamics and oxygenation in rats by a combined near-infrared spectroscopy and invasive probe approach |
| Autor(in); Institution |
Grosenick, Dirk; 8.3, Biomedizinische Optik, PTB-Berlin
Cantow, K.; Institut für Vegetative Physiologie, Charité Universitätsmedizin Berlin, GERMANY
Arakelyan, K.; Berlin Ultrahigh Field Facility (B.U.F.F.), Max-Delbrueck-Centrum für Molekulare Medizin, Berlin, GERMANY
Wabnitz, Heidrun; 8.3, Biomedizinische Optik, PTB-Berlin
Flemming, B.; Institut für Vegetative Physiologie, Charité Universitätsmedizin Berlin, GERMANY
Skalweit, A.; Institut für Vegetative Physiologie, Charité Universitätsmedizin Berlin, GERMANY
Ladwig, M.; Institut für Vegetative Physiologie, Charité Universitätsmedizin Berlin, GERMANY
Macdonald, Rainer; 8.3, Biomedizinische Optik, PTB-Berlin
Niendorf, Th.; Berlin Ultrahigh Field Facility (B.U.F.F.), Max-Delbrueck-Centrum für Molekulare Medizin, Berlin, GERMANY
Seelinger, E.; Institut für Vegetative Physiologie, Charité Universitätsmedizin Berlin, GERMANY
|
| Quelle/Jahr | Biomedical Optics Express: 6 (2015), 2, 309 - 323 |
| Availability | [online only] |
| ISSN | 2156-7085 |
| DOI | |
| Verlag | Washington, DC: Optical Society of America |
| Klassifikationscode | OCIS: 170.6510 ; OCIS: 170.2655 ; OCIS: 170.6935 |
| Freie Schlagworte | Near-infrared spectroscopy ; Functional monitoring ; Kidney oxygenation ; Renal hemodynamics |
| Zusammenfassung | We hypothesize that combining quantitative near-infrared spectroscopy (NIRS) with established invasive techniques will enable advanced insights into renal hemodynamics and oxygenation in small animal models. We developed a NIRS technique to monitor absolute values of oxygenated and deoxygenated hemoglobin and of oxygen saturation of hemoglobin within the renal cortex of rats. This NIRS technique was combined with invasive methods to simultaneously record renal tissue oxygen tension and perfusion. The results of test procedures including occlusions of the aorta or the renal vein, hyperoxia, hypoxia, and hypercapnia demonstrated that the combined approach, by providing different but complementary information, enables a more comprehensive characterization of renal hemodynamics and oxygenation. |
| Kostenfreier Zugang | Open Access Gold |
Zitierung
Grosenick, D., Cantow, K., Arakelyan, K., Wabnitz, H., Flemming, B., Skalweit, A., Ladwig, M., Macdonald, R., Niendorf, T., & Seelinger, E. (2015). Detailing renal hemodynamics and oxygenation in rats by a combined near-infrared spectroscopy and invasive probe approach. Biomedical Optics Express, 6(2), 309–323. http://doi.org/10.1364/boe.6.000309