| Zugriffsnummer | 32273 |
| Dokumenttyp | Zeitschriftenartikel |
| Peer Review | unbekannt |
| Sprache | Englisch |
| Titel | Oppositional COMT Val158Met effects on resting state functional connectivity in adolescents and adults |
| Autor(in); Institution |
Meyer, B.; Department of Psychiatry and Psychotherapy, Medical University of Vienna, AUSTRIA
Huemer, J.; Department of Child and Adolescent Psychiatry, Medical University of Vienna, AUSTRIA
Rabl, U.; Department of Psychiatry and Psychotherapy, Medical University of Vienna, AUSTRIA
Boubela, R.; MR Centre of Excellence, Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, AUSTRIA
Kalcher, K.; MR Centre of Excellence, Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, AUSTRIA
Berger, A.; Department of Psychiatry and Psychotherapy, Medical University of Vienna, AUSTRIA
IMAGEN consortium, ; IMAGEN consortium
Banaschewski, T.; Department of Child and Adolescent Psychiatry, Central Institute of Mental Health,Faculty of Clinical Medicine Mannheim, Medical Faculty Mannheim, Heidelberg University,Mannheim, GERMANY
Barker, G.; Centre for Neuroimaging Science, Institute of Psychiatry, King’s College London, London, UK
Bokde, A.; Institute of Neuroscience, Trinity College, IRELAND
Buechel, C.; University, Medical Centre Hamburg-Eppendorf, Hamburg, GERMANY
Conrod, P.; Department of Psychiatry, Université de Montreal, CHU St Justine Hosptial, CANADA
Ittermann, Bernd; 8.1, Medizinische Messtechnik, PTB-Berlin
|
| Quelle/Jahr | Brain Structure and Function:(2014) |
| ISSN | 1863-2653 (PRINT) ; 1863-2661 (ONLINE) |
| DOI | |
| Verlag | Berlin [u.a.]: Springer |
| Freie Schlagworte | Catechol O-Methyltransferase ; Dopamine ; Adolescents ; Cognition ; Functional Neuroimaging ; Magnetic Resonance Imaging |
| Zusammenfassung | Background: Prefrontal dopamine levels are relatively increased in adolescence compared to adulthood. Genetic variation of COMT (COMT Val158Met) results in lower enzymatic activity and higher dopamine availability in Met carriers. Given the dramatic changes of synaptic dopamine during adolescence, it has been suggested that effects of COMT Val158Met genotypes might have oppositional effects in adolescents and adults. The present study aims to identify such oppositional COMT Val158Met effects in adolescents and adults in prefrontal brain networks at rest. Methods: Resting state functional connectivity data were collected from cross-sectional and multi-center study sites involving 106 healthy young adults (mean age: 24 ± 2.6 years), gender-matched to 106 randomly chosen 14 year-olds. We selected the anterior medial prefrontal cortex (amPFC) as seed due to its important role as nexus in executive networks. Results: We observed a significant age-dependent reversal of COMT Val158Met effects on resting state functional connectivity between amPFC and ventrolateral prefrontal cortex, dorsolateral prefrontal cortex, and parahippocampal gyrus. Val homozygous adults exhibited increased and adolescents decreased connectivity compared to Met homozygotes for all reported regions. Network analyses underscored the importance of the parahippocampal gyrus as mediator of observed effects. Conclusions: Results of this study demonstrate that adolescent and adult resting state networks are dose-dependently and diametrically affected by COMT genotypes following a hypothetical model of dopamine function that follows an inverted U-shaped curve. This study might provide cues for the understanding of disease-onset or dopaminergic treatment mechanisms in major neuropsychiatric disorders such as schizophrenia and attention deficit hyperactivity disorder. |
Zitierung
Meyer, B., Huemer, J., Rabl, U., Boubela, R., Kalcher, K., Berger, A., IMAGEN consortium, Banaschewski, T., Barker, G., Bokde, A., Buechel, C., Conrod, P., & Ittermann, B. (2014). Oppositional COMT Val158Met effects on resting state functional connectivity in adolescents and adults. Brain Structure and Function. https://doi.org/10.1007/s00429-014-0895-5