| Zugriffsnummer | 31878 |
| Dokumenttyp | Zeitschriftenartikel |
| Peer Review | mit Peer Review |
| Sprache | Englisch |
| Titel | Performance assessment of time-domain optical brain imagers, part 1: basic instrumental performance protocol |
| Autor(in); Institution |
Wabnitz, Heidrun; 8.3, Biomedizinische Optik, PTB-Berlin
Taubert, Richard Dieter; 7.3, Detektorradiometrie und Strahlungsthermometrie, PTB-Berlin
Mazurenka, Mikhail; 8.3, Biomedizinische Optik, PTB-Berlin
Steinkellner, Oliver; 8.3, Biomedizinische Optik, PTB-Berlin
Jelzow, Alexander; 8.3, Biomedizinische Optik, PTB-Berlin
Macdonald, Rainer; 8.3, Biomedizinische Optik, PTB-Berlin
Milej, Daniel; Nalecz Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences, Warsaw, POLAND
Sawosz, Piotr; Nalecz Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences, Warsaw, POLAND
Kacprzak, Michal; Nalecz Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences, Warsaw, POLAND
Liebert, Adam; Nalecz Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences, Warsaw, POLAND
Cooper, Robert; University College London, Department of Medical Physics and Biomedical Engineering, London, UK
Hebden, Jeremy; University College London, Department of Medical Physics and Biomedical Engineering, London, UK
Pifferi, Antonio; Politecnico di Milano – Dipartimento di Fisica, Milano, ITALY
Farina, Andrea; Istituto di Fotonica e Nanotecnologie, CNR, Milano, ITALY
Bargigia, Ilaria; Istituto Italiano di Tecnologia, Center for Nano Science and Technology, Milano, ITALY
Contini, Davide; Politecnico di Milano – Dipartimento di Fisica, Milano, ITALY
Caffini, Matteo; Politecnico di Milano – Dipartimento di Fisica, Milano, ITALY
Zucchelli, Lucia; Politecnico di Milano – Dipartimento di Fisica, Milano, ITALY
Spinelli, Lorenzo; Istituto di Fotonica e Nanotecnologie, CNR, Milano, ITALY
Cubeddu, Rinaldo; Politecnico di Milano – Dipartimento di Fisica, Milano, ITALY
Torricelli, Alessandro; Politecnico di Milano – Dipartimento di Fisica, Milano, ITALY
|
| Quelle/Jahr | Journal of Biomedical Optics: 19 (2014), 8, 1 - 12 |
| Artikelnummer | 086010 |
| ISSN | 1083-3668 (PRINT) ; 1560-2281 (ONLINE) |
| DOI | |
| Verlag | Bellingham, Wash.: SPIE |
| Freie Schlagworte | optical brain imaging ; time-resolved measurements ; instrumentation ; performance assessment ; tissue-like phantoms |
| Zusammenfassung | Performance assessment of instruments devised for clinical applications is of key importance for validation and quality assurance. Two new protocols were developed and applied to facilitate the design and optimization of instruments for time-domain optical brain imaging within the European project nEUROPt. Here, we present the “Basic Instrumental Performance” protocol for direct measurement of relevant characteristics. Two tests are discussed in detail. First, the responsivity of the detection system is a measure of the overall efficiency to detect light emerging from tissue. For the related test, dedicated solid slab phantoms were developed and quantitatively spectrally characterized to provide sources of known radiance with nearly Lambertian angular characteristics. The responsivity of four time-domain optical brain imagers was found to be of the order of 0.1 m2 sr. The relevance of the responsivity measure is demonstrated by simulations of diffuse reflectance as a function of source-detector separation and optical properties. Second, the temporal instrument response function (IRF) is a critically important factor in determining the performance of time-domain systems. Measurements of the IRF for various instruments were combined with simulations to illustrate the impact of the width and shape of the IRF on contrast for a deep absorption change mimicking brain activation. |
| Kostenfreier Zugang | Open Access Hybrid |
| Rechteinformation | CC BY 3.0 ; Creative Commons Attribution 3.0 License |
Zitierung
Wabnitz, H., Taubert, R. D., Mazurenka, M., Steinkellner, O., Jelzow, A., Macdonald, R., Milej, D., Sawosz, P., Kacprzak, M., Liebert, A., Cooper, R., Hebden, J., Pifferi, A., Farina, A., Bargigia, I., Contini, D., Caffini, M., Zucchelli, L., Spinelli, L., Cubeddu, R., & Torricelli, A. (2014). Performance assessment of time-domain optical brain imagers, part 1: basic instrumental performance protocol. Journal of Biomedical Optics, 19(8), 1–12. https://doi.org/10.1117/1.jbo.19.8.086010