| Zugriffsnummer | 31543 |
| Dokumenttyp | Zeitschriftenartikel |
| Peer Review | unbekannt |
| Sprache | Englisch |
| Titel | No differences in hippocampal volume between carriers and non-carriers of the ApoE ε4 and ε2 alleles in young healthy adolescents. |
| Autor(in); Institution |
Khan, W.; King's College London, Institute of Psychiatry, London, UK; NIHR Biomedical Research Centre for Mental Health, King's College London, London, UK NIHR Biomedical Research Unit for Dementia, King's College London, London, UK
Giampietro, V.; King's College London, Institute of Psychiatry, London, UK
Ginestet, C.; King's College London, Institute of Psychiatry, London, UK; NIHR Biomedical Research Centre for Mental Health, King's College London, London, UK NIHR Biomedical Research Unit for Dementia, King's College London, London, UK
Dell'Acqua, F.; King's College London, Institute of Psychiatry, London, UK; NIHR Biomedical Research Centre for Mental Health, King's College London, London, UK NIHR Biomedical Research Unit for Dementia, King's College London, London, UK
Bouls, D.; King's College London, Institute of Psychiatry, London, UK; NIHR Biomedical Research Centre for Mental Health, King's College London, London, UK NIHR Biomedical Research Unit for Dementia, King's College London, London, UK
Newhouse, S.; King's College London, Institute of Psychiatry, London, UK; NIHR Biomedical Research Centre for Mental Health, King's College London, London, UK NIHR Biomedical Research Unit for Dementia, King's College London, London, UK
Dobson, R; King's College London, Institute of Psychiatry, London, UK; NIHR Biomedical Research Centre for Mental Health, King's College London, London, UK NIHR Biomedical Research Unit for Dementia, King's College London, London, UK
Banaschewski, T.; Central Institute of Mental Health, Mannheim, GERMANY; Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany
Barker, GJ; King's College London, Institute of Psychiatry, London, UK
Bokde, AL; Institute of Neuroscience and Discipline of Psychiatry, School of Medicine, Trinity College Dublin, Dublin, IRELAND
Büchel, C.; Universitaetsklinikum Hamburg Eppendorf, Hamburg, GERMANY
Conrod, PJ; Institute of Psychiatry, King's College London, London, UK
Ittermann, Bernd; 8.1, Medizinische Messtechnik, PTB-Berlin
the IMAGEN Consortium,
et al.,
|
| Quelle/Jahr | Journal of Alzheimer’s Disease: 40 (2014), 1, 37 - 43 |
| ISSN | 1387-2877 (PRINT) ; 1875-8908 (ONLINE) |
| DOI | |
| Verlag | Amsterdam: IOS Press |
| Freie Schlagworte | Apolipoprotein E ; hippocampal volume ; magnetic resonance imaging ; young healthy adolescents |
| Zusammenfassung | Alleles of the apolipoprotein E (ApoE) gene are known to modulate the genetic risk for developing late-onset Alzheimer's disease (AD) and have been associated with hippocampal volume differences in AD. However, the effect of these alleles on hippocampal volume in younger subjects has yet to be clearly established. Using a large cohort of more than 1,400 adolescents, this study found no hippocampal volume or hippocampal asymmetry differences between carriers and non-carriers of the ApoE ε4 or ε2 alleles, nor dose-dependent effects of either allele, suggesting that regionally specific effects of these polymorphisms may only become apparent in later life. |
| Weitere Informationen | 30 Authors, not all individual authors are listed ; 21 Institutions, not all institutions are listed |
Zitierung
Khan, W., Giampietro, V., Ginestet, C., Dell'Acqua, F., Bouls, D., Newhouse, S., Dobson, R., Banaschewski, T., Barker, G., Bokde, A., Büchel, C., Conrod, P., Ittermann, B., the IMAGEN Consortium, & et al. (2014). No differences in hippocampal volume between carriers and non-carriers of the ApoE ε4 and ε2 alleles in young healthy adolescents. Journal of Alzheimer’s Disease, 40(1), 37–43. https://doi.org/10.3233/jad-131841