| Zugriffsnummer | 30993 |
| Dokumenttyp | Zeitschriftenartikel |
| Peer Review | mit Peer Review |
| Sprache | Englisch |
| Titel | Separation of superficial and cerebral hemodynamics using a single distance time-domain NIRS measurement |
| Autor(in); Institution |
Jelzow, Alexander; 8.3, Biomedizinische Optik, PTB-Berlin
Wabnitz, Heidrun; 8.3, Biomedizinische Optik, PTB-Berlin
Tachtsidis, I.; University College London, Dept. Med. Physics and Bioengineering, London, UK
Kirilina, E.; FU Berlin,GERMANY
Brühl, Rüdiger; 8.1, Medizinische Messtechnik, PTB-Berlin
Macdonald, Rainer; 8.3, Biomedizinische Optik, PTB-Berlin
|
| Quelle/Jahr | Biomedical Optics Express: 5 (2014), 5, 1465 - 1481 |
| Availability | [online only] |
| ISSN | 2156-7085 |
| DOI | |
| Verlag | Washington, DC: Soc. |
| Klassifikationscode | OCIS: 170.5280 ; OCIS: 170.6920 ; OCIS: 170.3880 ; OCIS: 170.6510 ; OCIS: 120.3890 ; OCIS: 170.1470 |
| Freie Schlagworte | Photon migration ; Time-resolved imaging ; Medical and biological imaging ; Spectroscopy ; tissue diagnostics ; Medical optics instrumentation ; Blood or tissue constituent monitoring |
| Zusammenfassung | In functional near-infrared spectroscopy (fNIRS) superficial hemodynamics can mask optical signals related to brain activity. We present a method to separate superficial and cerebral absorption changes based on the analysis of changes in moments of time-of-flight distributions and a two-layered model. The related sensitivity factors were calculated from individual optical properties. The method was validated on a two-layer liquid phantom. Absorption changes in the lower layer were retrieved with an accuracy better than 20%. The method was successfully applied to in vivo data and compared to the reconstruction of homogeneous absorption changes. |
| Kostenfreier Zugang | Open Access Gold |
Zitierung
Jelzow, A., Wabnitz, H., Tachtsidis, I., Kirilina, E., Brühl, R., & Macdonald, R. (2014). Separation of superficial and cerebral hemodynamics using a single distance time-domain NIRS measurement. Biomedical Optics Express, 5(5), 1465–1481. https://doi.org/10.1364/boe.5.001465