| Zugriffsnummer | 30901 |
| Dokumenttyp | Konferenzartikel in Zeitschrift |
| Peer Review | unbekannt |
| Sprache | Englisch |
| Titel | Comparison of measured and Monte-Carlo simulated track structure parameters in nanometric volumes |
| Autor(in); Institution |
Hilgers, Gerhard; 6.6, Grundlagen der Dosimetrie, PTB-Braunschweig
Bug, Marion U.; 6.6, Grundlagen der Dosimetrie, PTB-Braunschweig; University of Wollongong, Centre for Medical Radiation Physics, Wollongong, AUSTRALIA
Gargioni, Elisabetta; Universitätsklinikum Hamburg-Eppendorf, Hamburg, GERMANY
Rabus, Hans; 6.6, Grundlagen der Dosimetrie, PTB-Braunschweig
|
| Quelle/Jahr | Radiation Protection Dosimetry: 161 (2014), 1/4, 441 - 444 |
| ISSN | 0144-8420 (PRINT) ; 1742-3406 (ONLINE) |
| DOI | |
| URL | |
| Verlag | Oxford: Oxford University Press |
| Konferenzangaben | 12th Neutron and Ion Dosimetry Symposium, Aix-en-Provence, 03-07, June, 2013, France |
| Freie Schlagworte | nanodosimetry ; Monte Carlo simulation ; track structure |
| Zusammenfassung | Radiation induced damage to tissue is strongly influenced by the pattern of inelastic interactions in sub-cellular targets, especially in the DNA, which is carrying the genetic information. For assessment of the biological effectiveness of ionizing radiation, the track structure of ionizing particles within a target volume the size of a DNA segment is of particular importance. The track structure of ionizing particles in biological matter can only be assessed by simulating the particle track in condensed matter. Hence, there is a need to benchmark these computer codes using suitable experimental data. A characteristic parameter for the track structure of an ionizing particle is the number of ionizations which are produced when traversing a volume element filled with matter. This quantity, referred to as the ionization cluster size, is amenable to measurement using an ion-counting nanodosimeter, which consists basically of a gas-filled counter operated at low pressure [1]. Ionization cluster size distributions produced in the nanodosimeter’s sensitive volume by monoenergetic protons and α-particles (with energies between 0.1 MeV and 20 MeV) were measured at the PTB ion accelerator facilities. C3H8 and N2 were alternately used as the working gas. The measured data were compared with the results of simulations obtained with the PTB Monte Carlo code PTra. Measured and simulated characteristics of the particle track structure are in good agreement for protons over the entire energy range investigated. For αparticles with energies above the Bragg peak a good agreement can also be seen, whereas for energies below the Bragg peak differences of as much as 25% occur. References [1] G. Garty et al.: The performance of a novel ion-counting nanodosimeter. Nucl. Instrum. Meth. A 492, 212-235, 2002. |
