| Zugriffsnummer | 29616 |
| Dokumenttyp | Konferenzartikel in Zeitschrift |
| Peer Review | mit Peer Review |
| Sprache | Englisch |
| Titel | Radiation damage of biomolecules (RADAM) database development: current status |
| Autor(in); Institution |
Denifl, S.; Institut für Ionenphysik und Angewandte Physik, Innsbruck, AUSTRIA
Garcia, G.; Instituto de Fisica Fundamental, Madrid, SPAIN
Huber, B. A.; Centre de Recherche sur les Ions, la Matière et la Photonique, Caen, FRANCE
Marinkovic, B. P.; Institute of Physics, University of Belgrade, SERBIA
Mason, N.; Open University, Faculty of Science, Milton Keynes, UK
Postler, J.; Institut für Ionenphysik und Angewandte Physik, Innsbruck, AUSTRIA
Rabus, Hans; 6.6, Grundlagen der Dosimetrie, PTB-Braunschweig
Rixon, G.; Open University, Faculty of Science, Milton Keynes, UK
Solov'yov, A. V.; Frankfurt Institute for Advanced Studies, Frankfurt am Main, GERMANY
Suraud, E.; Laboratoire de Physique théorique, Université Paul Sabatier, Toulouse, FRANCE
Yakubovich, A. V.; Frankfurt Institute for Advanced Studies, Frankfurt am Main, GERMANY
|
| Quelle/Jahr | Journal of Physics: Conference series: 438 (2013), 1 - 8 |
| Artikelnummer | 012016 |
| ISSN | 1742-6596 |
| DOI | |
| Verlag | Bristol: IOP |
| Konferenzangaben | International Conference on "Dynamic of Systems on the Nanoscale", Saint Petersburg, 30, September - 4, October, 2012, Russia |
| Klassifikationscode | PACS: 87.53.-j ; PACS: 87.53.Bn ; PACS: 87.10.-e ; PACS: 87.19.X- |
| Freie Schlagworte | Ion beam therapy ; Cross sections ; Track structure ; Biomolecules |
| Zusammenfassung | Ion beam therapy offers the possibility of excellent dose localization for treatment of malignant tumours, minimizing radiation damage in normal tissue, while maximizing cell killing within the tumour. However, as the underlying dependent physical, chemical and biological processes are too complex to treat them on a purely analytical level, most of our the current and future understanding will rely on computer simulations, based on mathematical equations, algorithms and last but not least on the available atomic and molecular data. The viability of the simulated output and the success of any computer simulation is determined by these data, which are treated as the input variables in each computer simulation performed. The radiation research community lacks a complete database for the cross sections of all the different processes involved in ion beam induced damage: ionization and excitation cross sections for ions with liquid water and biological molecules, all the possible electron - medium interactions, dielectric response data, electron attachment to biomolecules etc. In this paper we discuss current progress in the creation of such a database, outline the roadmap of the project and review plans for the exploitation of such a database in future simulations. |
| Kostenfreier Zugang | Freier Zugang |
| Rechteinformation | CC BY 3.0 ; Creative Commons Attribution 3.0 License |
Zitierung
Denifl, S., Garcia, G., Huber, B. A., Marinkovic, B. P., Mason, N., Postler, J., Rabus, H., Rixon, G., Solov'yov, A. V., Suraud, E., & Yakubovich, A. V. (2013). Radiation damage of biomolecules (RADAM) database development: current status. Journal of Physics: Conference series, 438, 1–8. https://doi.org/10.1088/1742-6596/438/1/012016