| Zugriffsnummer | 29571 |
| Dokumenttyp | Konferenzartikel |
| Sprache | Englisch |
| Titel | A Non-contact time-domain scanning brain imaging system: First in-vivo results |
| Autor(in); Institution |
Mazurenka, Mikhail; 8.3, Biomedizinische Optik, PTB-Berlin
Di Sieno, L.; Dipartimento di Fisica, Politecnico di Milano, Milano, ITALY
Boso, G.; Dipartimento di Elettronica e Informazione, Politecnico di Milano, Milano, ITALY
Contini, D.; Dipartimento di Fisica, Politecnico di Milano, Milano, ITALY
Pifferi, A.; Dipartimento di Fisica, Politecnico di Milano, Milano, ITALY
Dalla Mora, A.; Dipartimento di Fisica, Politecnico di Milano, Milano, ITALY
Tosi, A.; Dipartimento di Elettronica e Informazione, Politecnico di Milano, Milano, ITALY
Wabnitz, Heidrun; 8.3, Biomedizinische Optik, PTB-Berlin
Macdonald, Rainer; 8.3, Biomedizinische Optik, PTB-Berlin
|
| Quelle/Jahr | Diffuse optical imaging IV: 12 - 14 May 2013, Munich, Germany:(2013), 87990L-1 - 87990L-7 |
| Schriftenreihe | Proceedings of SPIE: 8799 |
| Availability | [CD-ROM] ; file name: 8799_8.pdf |
| Herausgeber(in) |
Taroni, Paola
Dehghani, Hamid
|
| ISBN | 978-081-949-648-5 |
| DOI | |
| Verlag | Bellingham, Wash.: SPIE |
| Konferenzangaben | European Conferences on Biomedical Optics (ECBO), Diffuse Optical Imaging IV, München, 12-16, May, 2013, Germany |
| Freie Schlagworte | time-domain NIRS ; single-photon avalanche diode ; non-contact imaging |
| Zusammenfassung | We present results of first in-vivo tests of an optical non-contact scanning imaging system, intended to study oxidative metabolism related processes in biological tissue by means of time-resolved near-infrared spectroscopy. Our method is a novel realization of the short source-detector separation approach and based on a fast-gated single-photon avalanche diode to detect late photons only. The scanning system is built in quasi-confocal configuration and utilizes polarization-sensitive detection. It scans an area of 4x4 cm^2, recording images with 32x32 pixels, thus creating a high density of source-detector pairs. To test the system we performed a range of in vivo measurements of hemodynamic changes in several types of biological tissues, i.e. skin (Valsalva maneuver), muscle (venous and arterial occlusions) and brain (motor and cognitive tasks). Task-related changes in hemoglobin concentrations were clearly detected in skin and muscle. The brain activation shows weaker, but yet detectable changes. These changes were localized in pixels near the motor cortex area (C3). However, it was found that even very short hair substantially impairs the measurement. Thus the applicability of the scanner is limited to hairless parts of body. The results of our first in-vivo tests prove the feasibility of non-contact scanning imaging as a first step towards development of a prototype for biological tissue imaging for various medical applications. |
Zitierung
Mazurenka, M., Di Sieno, L., Boso, G., Contini, D., Pifferi, A., Dalla Mora, A., Tosi, A., Wabnitz, H., & Macdonald, R. (2013). A Non-contact time-domain scanning brain imaging system: First in-vivo results. European Conferences on Biomedical Optics (ECBO), Diffuse Optical Imaging IV, München, 12-16, May, 2013, Germany. https://doi.org/10.1117/12.2032386