| Zugriffsnummer | 29410 |
| Dokumenttyp | Zeitschriftenartikel |
| Peer Review | unbekannt |
| Sprache | Englisch |
| Titel | Genetic risk for nicotine dependence in the cholinergic system and activation of the brain reward system in healthy adolescents |
| Autor(in); Institution |
Nees, F.; Central Institute of Mental Health, Mannheim, GERMANY
Witt, S.H.; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
Lourdusamy, A.; Institute of Psychiatry, King's College London, UK
Vollstädt-Klein, S.; Departments of Addictive Behaviour and Addiction Medicine, Heidelberg University, Mannheim, GERMANY
Steiner, S.; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Heidelberg, GERMANY
Poustka, L.; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Banaschewski, T.; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Barker, G.J.; Institute of Psychiatry, King's College London, UK
Büchel, C.; NeuroImage Nord, Department of Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg, GERMANY
Conrod, PJ.; Institute of Psychiatry, King's College London, UK
Frank, J.; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
Gallinat, J.; Psychiatry and Psychotherapy, Charité – Universitätsmedizin, Berlin, GERMANY
Ittermann, Bernd; 8.1, Medizinische Messtechnik, PTB-Berlin
the IMAGEN Consortium,
et al.,
|
| Quelle/Jahr | Neuropsychopharmacology: 38 (2013), 2081 - 2089 |
| ISSN | 0893-133X (PRINT) ; 1740-634X |
| DOI | |
| Verlag | Basingstoke: Nature Publishing Group |
| Zusammenfassung | Genetic variation in a genomic region on chromosome 15q25.1, which encodes the alpha5, alpha3, and beta4 subunits of the cholinergic nicotinic receptor genes, confers risk to smoking and nicotine dependence (ND). Neural reward-related responses have previously been identified as important factors in the development of drug dependence involving ND. Applying an imaging genetics approach in two cohorts (N=487; N=478) of healthy non-smoking adolescents, we aimed to elucidate the impact of genome-wide significant smoking-associated variants in the CHRNA5- CHRNA3-CHRNB4 gene cluster on reward-related neural responses in central regions such as the striatum, orbitofrontal and anterior cingulate cortex (ACC), and personality traits related to addiction. In both samples, carriers of the rs578776 GG compared with AG/AA genotype showed a significantly lower neural response to reward outcomes in the right ventral and dorsal ACC but not the striatum or the orbitofrontal cortex. Rs578776 was unrelated to neural reward anticipation or reward magnitude. Significantly higher scores of anxiety sensitivity in GG compared with AG/AA carriers were found only in sample 1. Associations with other personality traits were not observed. Our findings suggest that the rs578776 risk variant influences susceptibility to ND by dampening the response of the ACC to reward feedback, without recruiting the striatum or orbitofrontal cortex during feedback or anticipation. Thus, it seems to have a major role in the processing of and behavioral adaptation to changing reward outcomes. |
| Weitere Informationen | 25 authors, not all individual authors are listed ; 18 institutions, not all institutions are listed |
Zitierung
Nees, F., Witt, S., Lourdusamy, A., Vollstädt-Klein, S., Steiner, S., Poustka, L., Banaschewski, T., Barker, G., Büchel, C., Conrod, P., Frank, J., Gallinat, J., Ittermann, B., the IMAGEN Consortium, & et al. (2013). Genetic risk for nicotine dependence in the cholinergic system and activation of the brain reward system in healthy adolescents. Neuropsychopharmacology, 38, 2081–2089. https://doi.org/10.1038/npp.2013.131