| Zugriffsnummer | 29409 |
| Dokumenttyp | Zeitschriftenartikel |
| Peer Review | unbekannt |
| Sprache | Englisch |
| Titel | Neural mechanisms of attention-deficit/hyperactivity disorder symptoms are stratified by MAOA genotype |
| Autor(in); Institution |
Nymberg, C.; Institute of Psychiatry, King’s College London, London, UK
Jia, T.; Institute of Psychiatry, King’s College London, London, UK
Lubbe, S.; Institute of Psychiatry, King’s College London, London, UK
Ruggeri, B.; Institute of Psychiatry, King’s College London, London, UK
Desrivieres, S.; Institute of Psychiatry, King’s College London, London, UK
Barker, GJ.; Institute of Psychiatry, King’s College London, London, UK
Büchel, C.; University Medical Centre Hamburg-Eppendorf (CB, FN), Hamburg, GERMANY
Fauth-Buehler, M.; Department of Addictive Behaviour and Addiction Medicine (MF-B, KM), and Department of Cognitive and Clinical Neuroscience (HF), Central Institute of Mental Health, University of Heidelberg, Mannheim, GERMANY
Cattrell, A.; Institute of Psychiatry, King’s College London, London, UK
Conrod, P.; Institute of Psychiatry, King’s College London, London, UK
Flor, H.; Department of Psychiatry and Psychotherapy (JG, AH), Charité—Universitätsmedizin Berlin, Berlin, GERMANY
Gallinat, J.; Department of Psychiatry and Psychotherapy (JG, AH), Charité—Universitätsmedizin Berlin, Berlin, GERMANY
Ittermann, Bernd; 8.1, Medizinische Messtechnik, PTB-Berlin
the IMAGEN Consortium,
et al.,
|
| Quelle/Jahr | Biological psychiatry: 74 (2013), 8, 607 - 614 |
| ISSN | 0006-3223 |
| DOI | |
| Verlag | New York, NY: Elsevier |
| Zusammenfassung | Attention-deficit/hyperactivity disorder (ADHD) is characterized by deficits in reward sensitivity and response inhibition. The relative contribution of these frontostriatal mechanisms to ADHD symptoms and their genetic determinants is largely unexplored. Using functional magnetic resonance imaging and genetic analysis of the monoamine oxidase A (MAOA) gene, we investigated how striatal and inferior frontal activation patterns contribute to ADHD symptoms depending on MAOA genotype in a sample of adolescent boys (n = 190). We demonstrate an association of ADHD symptoms with distinct blood oxygen leveldependent (BOLD) responses depending on MAOA genotype. In A hemizygotes of the expression single nucleotide polymorphism rs12843268, which express lower levels of MAOA, ADHD symptoms are associated with lower ventral striatal BOLD response during the monetary incentive delay task and lower inferior frontal gyrus BOLD response during the stop signal task. In G hemizygotes, ADHD symptoms are associated with increased inferior frontal gyrus BOLD response during the stop signal task in the presence of increased ventral striatal BOLD response during the monetary incentive delay task. Depending on MAOA genotype, ADHD symptoms in adolescent boys are associated with either reward deficiency or insufficient response inhibition. Apart from its mechanistic interest, our finding may aid in developing pharmacogenetic markers for ADHD. |
| Weitere Informationen | 28 authors, not all individual authors are listed ; 16 institutions, not all institutions are listed |
Zitierung
Nymberg, C., Jia, T., Lubbe, S., Ruggeri, B., Desrivieres, S., Barker, G., Büchel, C., Fauth-Buehler, M., Cattrell, A., Conrod, P., Flor, H., Gallinat, J., Ittermann, B., the IMAGEN Consortium, & et al. (2013). Neural mechanisms of attention-deficit/hyperactivity disorder symptoms are stratified by MAOA genotype. Biological psychiatry, 74(8), 607–614. https://doi.org/10.1016/j.biopsych.2013.03.027