| Zugriffsnummer | 29331 |
| Dokumenttyp | Zeitschriftenartikel |
| Sprache | Englisch |
| Titel | Validation of isotope dilution surface-enhanced raman scattering (IDSERS) as a higher order reference method for clinical measurands employing international comparison schemes. |
| Autor(in); Institution |
Zakel, Sabine; 3.1, Metrologie in der Chemie, PTB-Braunschweig
Wundrack, Stefan; 3.1, Metrologie in der Chemie, PTB-Braunschweig
O’Connor, Gavin; LGC, Teddington, TW11OLY, UK
Güttler, Bernd; 3.1, Metrologie in der Chemie, PTB-Braunschweig
Stosch, Rainer; 3.1, Metrologie in der Chemie, PTB-Braunschweig
|
| Quelle/Jahr | Journal of Raman Spectroscopy: 44 (2013), 9, 1246 - 1252 |
| ISSN | 0377-0486 (PRINT) ; 1097-4555 (ONLINE) |
| DOI | |
| Verlag | Chichester [u.a.]: Wiley |
| Freie Schlagworte | Surface-enhanced Raman scattering ; SERS ; isotope dilution ; diagnostic marker ; creatinine ; serum ; reference method ; SI Traceability ; ring-trial ; EURAMET |
| Zusammenfassung | Isotope dilution surface-enhanced Raman scattering (IDSERS) was established as a higher order reference measurement method for clinical measurands in international comparison schemes in direct comparison to established mass spectrometric methods. IDSERS represents the most accurate and precise quantitative Raman technique and is capable to provide SI-traceable amount-of-substance measurements. IDSERS has now been validated by participation in two international ring trials organized in the framework oft he meter convention on the determination of biomarkers in human serum. The concentration of creatinine has been measured in two human serum samples supplied by the study organizer. The results obtained by IDSERS agree excellently with the data reported by participating national metrology institutes using mass spectrometry and the associated uncertainties are within the claimed limits of equivalence. The performance and applicability of IDSERS as a higher order reference procedure was thereby convincingly demonstratet. |
Zitierung
Zakel, S., Wundrack, S., O’Connor, G., Güttler, B., & Stosch, R. (2013). Validation of isotope dilution surface-enhanced raman scattering (IDSERS) as a higher order reference method for clinical measurands employing international comparison schemes. Journal of Raman Spectroscopy, 44(9), 1246–1252. https://doi.org/10.1002/jrs.4349