| Zugriffsnummer | 29166 |
| Dokumenttyp | Zeitschriftenartikel |
| Peer Review | unbekannt |
| Sprache | Englisch |
| Titel | From gene to brain to behavior: schizophrenia-associated variation in AMBRA1 alters impulsivity-related traits |
| Autor(in); Institution |
Heinrich, A.; Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Nees, F.; Central Institute of Mental Health, Mannheim, GERMANY
Lourdusamy, A.; Institute of Psychiatry, King's College London, UK
Tzschoppe, J.; Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Vollstädt-Klein, S.; Departments of Addictive Behaviour and Addiction Medicine, Heidelberg University, Mannheim, GERMANY
Fauth-Bühler, M.; Departments of Addictive Behaviour and Addiction Medicine, Heidelberg University, Mannheim, GERMANY
Steiner, S.; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Heidelberg, GERMANY
Bach, C.; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Poustka, L.; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Banaschewski, T.; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Barker, G.; Institute of Psychiatry, King's College London, UK
Büchel, C.; NeuroImage Nord, Department of Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg, GERMANY
Conrod, P.; Institute of Psychiatry, King's College London, UK
Garavan, H.; Departments of Psychiatry and Psychology, University of Vermont, Burlington, VT, USA
Ittermann, Bernd; 8.1, Medizinische Messtechnik, PTB-Berlin
et al.,
|
| Quelle/Jahr | European Journal of Neuroscience: 38 (2013), 6, 2941 - 2945 |
| ISSN | 0953-816X (PRINT) ; 1460-9568 (ONLINE) |
| DOI | |
| Verlag | Oxford: Blackwell Science |
| Zusammenfassung | Recently, genome-wide association between schizophrenia and an intronic variant in AMBRA1 (rs11819869) was reported. Additionally, in a reverse genetic approach in adult healthy subjects, risk allele carriers showed a higher medial prefrontal cortex blood oxygen level-dependent (BOLD) response during a flanker task examining motor inhibition as an aspect of impulsivity. To test whether this finding can be expanded to further aspects of impulsivity, we analysed the effects of the rs11819869 genotype on impulsivity-related traits on a behavioral, temperament and neural level in a large sample of healthy adolescents. We consider this reverse genetic approach specifically suited for use in a healthy adolescent sample, as these individuals comprise those who will eventually develop mental disorders in which impulsivity is implicated. Healthy adolescents from the IMAGEN study were included in the neuropsychological analysis (n = 848) and a functional magnetic resonance imaging (fMRI) task (n = 512). Various aspects of impulsivity were assessed using the Temperament and Character Inventory-Revised, the Substance Use Risk Profile Scale, the Cambridge Cognition Neuropsychological Test Automated Battery, and the Stop Signal Task (SST) in the fMRI paradigm. On a behavioral level, increased delay aversion was observed in risk allele carriers. Furthermore, risk allele carriers showed a higher BOLD response in an orbito-frontal target region during the SST, which declined to trend status after Family Wise Error correction. Our findings support the hypothesis that the schizophrenia-related risk variant of rs11819869 is involved in various aspects of impulsivity, and that this involvement occurs on a behavioral as well as an imaging genetics level. |
| Weitere Informationen | 31 authors, not all individual authors are listed ; 18 institutions, not all institutions are listed |
Zitierung
Heinrich, A., Nees, F., Lourdusamy, A., Tzschoppe, J., Vollstädt-Klein, S., Fauth-Bühler, M., Steiner, S., Bach, C., Poustka, L., Banaschewski, T., Barker, G., Büchel, C., Conrod, P., Garavan, H., Ittermann, B., & et al. (2013). From gene to brain to behavior: schizophrenia-associated variation in AMBRA1 alters impulsivity-related traits. European Journal of Neuroscience, 38(6), 2941–2945. https://doi.org/10.1111/ejn.12201