| Zugriffsnummer | 29088 |
| Dokumenttyp | Konferenzartikel |
| Sprache | Englisch |
| Titel | Towards theranostics of rheumatoid arthritis: 1H/19F imaging of non-steroidal anti-inflammatory drugs in hand and wrist at 7 Tesla |
| Autor(in); Institution |
Waiszies, H.; Magnetic Resonance Imaging in Immunology, Experimental and Clinical Research Center (ECRC), a cooperation of the Charité Medical Faculty and the Max Delbrück Center for Molecular Medicine, Berlin, GERMANY
Kühne, Patrick; 8.1, Medizinische Messtechnik, PTB-Berlin
Winter, L.; Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrück Center for Molecular Medicine, Berlin, GERMANY
Frauenrath, T.; Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrück Center for Molecular Medicine, Berlin, GERMANY
Hoffmann, Werner; 8.1, Medizinische Messtechnik, PTB-Berlin
Ittermann, Bernd; 8.1, Medizinische Messtechnik, PTB-Berlin
Waiczies, S.; Magnetic Resonance Imaging in Immunology, Experimental and Clinical Research Center (ECRC), a cooperation of the Charité Medical Faculty and the Max Delbrück Center for Molecular Medicine, Berlin, GERMANY
Niendorf, T.; Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrück Center for Molecular Medicine, Berlin, GERMANY
|
| Quelle/Jahr | ISMRM 21th annual meeting & exhibition: 20-26 April 2013; Salt Lake City, USA:(2013), 3504 |
| Availability | [CD-ROM] ; file name: 3504.pdf |
| ISSN | 1545-4428 |
| Verlag | Berkeley, Calif.: ISMRM |
| Konferenzangaben | ISMRM 21th Annual Meeting & Exhibition, Salt Lake City, 20-26, April, 2013, USA |
| Zusammenfassung | Rheumatoid arthritis (RA) is a chronic and systemic inflammatory condition of the skeletal system that also affects adults within the prime of their work productivity. By targeting synovial tissue, cartilage and bone, RA is a debilitating condition since it significantly hinders the physical functioning and working capacity of an individual [1]. While the therapeutic armamentarium for RA is extensive, a comprehensive diagnosis of the disease (particularly knowledge of the exact location of inflammation) during early stages of disease is central for preventing and delaying further disease progression. New emerging MRI technologies to study cartilage composition include gadolinium enhanced cartilage imaging, 23Na-MRI and T2 relaxation mapping [2]. 19F-MRI has become increasingly important for small animal imaging in multiple fields of pre-clinical research including cell tracking and detection of inflammation [3]. Since 19F containing molecules are scarce in the human body, administration of exogenous fluorine containing compounds such as non-steroidal anti-inflammatory drugs (NSAIDs) will give a background free signal in 19F MRI. This study involves the development of a double-tuned 1H/19F birdcage resonator and examines its applicability for hand and wrist 19F imaging at 7 T following topical application of the NSAID 2-\{[3-(Trifluoromethyl) phenyl]amino\}benzoic acid. References: [1] Burton W, Morrison A, Maclean R, Ruderman E (2006) Systematic review of studies of productivity loss due to rheumatoid arthritis. Occup Med (Lond) 56: 18-27. [2] Borrero CG, Mountz JM, Mountz JD (2011) Emerging MRI methods in rheumatoid arthritis. Nat Rev Rheumatol 7: 85-95. [3] Ruiz-Cabello J, Barnett BP, Bottomley PA, Bulte JW (2011) Fluorine (19F) MRS and MRI in biomedicine. NMR Biomed 24: 114-129. [4] Christ A et al. (2010) The Virtual Family – development of surface-based anatomical models of two adults and two children for dosimetric simulations. Phys Med Biol. 2010, 55: N23-38 |
Zitierung
Waiszies, H., Kühne, P., Winter, L., Frauenrath, T., Hoffmann, W., Ittermann, B., Waiczies, S., & Niendorf, T. (2013). Towards theranostics of rheumatoid arthritis: 1H/19F imaging of non-steroidal anti-inflammatory drugs in hand and wrist at 7 Tesla. ISMRM 21th Annual Meeting & Exhibition, Salt Lake City, 20-26, April, 2013, USA.