| Zugriffsnummer | 29052 |
| Dokumenttyp | Zeitschriftenartikel |
| Peer Review | unbekannt |
| Sprache | Englisch |
| Titel | The risk variant in ODZ4 for bipolar disorder impacts on amygdala activation during reward processing |
| Autor(in); Institution |
Heinrich, A.; Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Lourdusamy, A.; Institute of Psychiatry, King's College London, UK
Tzschoppe, J.; Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Vollstädt-Klein, S.; Departments of Addictive Behaviour and Addiction Medicine, Mannheim, GERMANY
Bühler, M.; Departments of Addictive Behaviour and Addiction Medicine, Mannheim, GERMANY
Steiner, S.; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Heidelberg, GERMANY
Bach, C.; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Poustka, L.; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Banaschewski, T.; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, GERMANY
Barker, G.; Institute of Psychiatry, King's College London, UK
Büchel, C.; NeuroImage Nord, Department of Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg, GERMANY
Conrod, P.; Institute of Psychiatry, King's College London, UK
Garavan, H.; Departments of Psychiatry and Psychology, University of Vermont, Burlington, VT, USA
Ittermann, Bernd; 8.1, Medizinische Messtechnik, PTB-Berlin
et al.,
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| Quelle/Jahr | Bipolar Disorders: 15 (2013), 4, 440 - 445 |
| ISSN | 1398-5647 (PRINT) ; 1399-5618 (ONLINE) |
| DOI | |
| Verlag | Oxford: Wiley-Blackwell |
| Freie Schlagworte | amygdala ; bipolar disorder ; imaging genetics ; reward processing ; ventral striatum |
| Zusammenfassung | Objectives Bipolar disorder is a severe mood disorder, which normally begins during adolescence or early adulthood and has a heritability of up to 80%. The largest genome-wide association analysis of bipolar disorder recently identified a new genome-wide associated variant in OZD4 (rs12576775). The aim of the present study was to further elucidate the role of this risk variant in the disease process using an imaging genetics approach. As increased amygdala and striatal responses during the processing of reward and emotion are characteristic for bipolar disorder patients, it was tested whether the risk variant has an influence on this endophenotype in healthy adolescents. Methods We examined the impact of the risk variant rs12576775 on functional magnetic resonance imaging data in an adolescent sample (N = 485). Differential activation between carriers of the risk allele (G-allele) and homozygous A-allele carriers in the amygdala and the striatum during a modification of the monetary incentive delay task (examining reward) and a face task (examining emotion) was analyzed. Results Carriers of the risk allele showed an increased blood oxygen level-dependent response in the amygdala during reward sensitivity (p = 0.05) and reward expectation (p ( 0.05) but not during the face task. No significant group differences were found in the striatum during both reward and emotion processing. Conclusion Our results indicate that the ODZ4 risk variant influences reward processing in the amygdala. Alterations in the processing of emotion may have different underlying mechanisms and need to be further examined. |
| Weitere Informationen | 29 authors, not all individual authors are listed ; 29 institutions, not all institutions are listed |
Zitierung
Heinrich, A., Lourdusamy, A., Tzschoppe, J., Vollstädt-Klein, S., Bühler, M., Steiner, S., Bach, C., Poustka, L., Banaschewski, T., Barker, G., Büchel, C., Conrod, P., Garavan, H., Ittermann, B., & et al. (2013). The risk variant in ODZ4 for bipolar disorder impacts on amygdala activation during reward processing. Bipolar Disorders, 15(4), 440–445. https://doi.org/10.1111/bdi.12068