| Zugriffsnummer | 28898 |
| Dokumenttyp | Konferenzartikel |
| Peer Review | unbekannt |
| Sprache | Englisch |
| Titel | Reduced amygdala volume in smokers |
| Autor(in); Institution |
Schubert, Florian; 8.1, Medizinische Messtechnik, PTB-Berlin
Kühn, S.; Max-Planck-Institut für Bildungsforschung, Berlin, GERMANY
Mekle, Ralf; 8.1, Medizinische Messtechnik, PTB-Berlin
Gallinat, J.; Clinic for Psychiatry and Psychotherapy, Charité University Medicine, Berlin, GERMANY
Ittermann, Bernd; 8.1, Medizinische Messtechnik, PTB-Berlin
|
| Quelle/Jahr | ISMRM 21th annual meeting & exhibition: 20-26 April 2013; Salt Lake City, USA:(2013), 1241 |
| Availability | [CD-ROM] ; file name: 1241.pdf |
| ISSN | 1545-4428 |
| Verlag | Berkeley, Calif.: ISMRM |
| Konferenzangaben | ISMRM 21th Annual Meeting & Exhibition, Salt Lake City, 20-26, April, 2013, USA |
| Freie Schlagworte | 3T ; amygdala volume ; smoking ; addiction |
| Zusammenfassung | Tobacco remains the biggest, yet most preventable cause of death worldwide. Of emerging concern in the neurobiology of nicotine addiction is the integrity of the amygdala. We used high-resolution MR imaging at 3 tesla to measure the amygdala volume of 26 smokers, 25 ex-smokers and 25 never-smokers, and explored the results for relationship to smoking behavior. Anatomical images were acquired using an MPRAGE sequence; for volumetry of brain structures the software packages Freesurfer and FSL were used. ANOVA controlled for intracranial volume, age and sex showed the volume of the amygdala to be significantly larger in never-smokers than in ex-smokers and smokers. With increasing number of pack years, ie number of cigarettes smoked over a long period of time, the total amygdala volume was significantly reduced. These findings are in line with emerging evidence for a role of the amygdala in nicotine dependence and may help to find strategies for its manipulation to impact on the effects of nicotine. References 1. www.emro.who.int/press-releases/2008/the-who-report-on-the-global- tobacco-epidemic-2008.html 2. Dani JA and Harris RA, Nature Neurosci 2005; 8: 1465 3. Durazzo TC et al, Alzheimers Dement 2012; 8: 513 4. Gallinat J et al, Eur J Neurosci 2006; 24: 1744 5. Mihov Y and Hurlemann R, Neuropsychologia 2012; 50: 1719 6. Markou A, Phil Trans R Soc B 2008; 363: 3159 7. Haghighi A et al, Arch Gen Psychiatry 2012; doi: 10.1001/archgenpsychiatry.2012.1101 8. http://surfer.nmr.mgh.harvard.edu |
