| Zugriffsnummer | 28882 |
| Dokumenttyp | Zeitschriftenartikel |
| Peer Review | unbekannt |
| Sprache | Englisch |
| Titel | Effects of age and sex on the concentrations of glutamate and glutamine in the human brain |
| Autor(in); Institution |
Hädel, S.; Charité University Medicine, St. Hedwig Krankenhaus, Clinic for Psychiatry and Psychotherapy, Berlin, GERMANY; Ghent University, Faculty of Psychology and Educational Sciences, Department of Experimental Psychology, Ghent Institute for Functional and Metabolic Imaging, Gent, BELGIUM
Wirth, C.; Charité University Medicine, St. Hedwig Krankenhaus, Clinic for Psychiatry and Psychotherapy, Berlin, GERMANY
Rapp, M.; Charité University Medicine, St. Hedwig Krankenhaus, Clinic for Psychiatry and Psychotherapy, Berlin, GERMANY
Gallinat, J.; Charité University Medicine, St. Hedwig Krankenhaus, Clinic for Psychiatry and Psychotherapy, Berlin, GERMANY
Schubert, Florian; 8.1, Medizinische Messtechnik, PTB-Berlin
|
| Quelle/Jahr | Journal of Magnetic Resonance Imaging: 38 (2013), 6, 1480 - 1487 |
| ISSN | 1053-1807 (PRINT) ; 1522-2586 (ONLINE) |
| DOI | |
| Verlag | Hoboken, NJ: Wiley |
| Zusammenfassung | PURPOSE: To determine the effects of age and sex on cerebral glutamate and glutamine concentrations in a large sample of healthy humans using a dedicated measuring and evaluation procedure. Exploratory examinations of other brain metabolites were also conducted. MATERIALS AND METHODS: In 118 healthy subjects aged 19 to 55 years (59 female) absolute concentrations of glutamate, glutamine, N-acetylaspartate (NAA), total creatine, and total choline (tCho) in voxels comprising the left hippocampus (HC) and the anterior cingulate cortex (ACC) were investigated using point-resolved spectroscopy with an echo time of 80 ms at 3 Tesla in combination with a reliable quantification procedure. Special care was taken to correct for multiple comparisons. RESULTS: An age-related decline of the concentrations of glutamate in both regions studied was observed whereas glutamine levels in ACC increased with age. Statistically significant sex-related differences were detected for glutamate in the HC and for tCho in the ACC. NAA decreased with age in both regions, the significance not surviving Bonferroni correction. CONCLUSION: The results demonstrate effects of age and gender on glutamate, glutamine, choline containing compounds, and NAA in healthy human brain. They add to the growing evidence for gender-specific differences in cerebral neurotransmission, metabolism, and structure across the lifespan. |
