| Zugriffsnummer | 28769 |
| Dokumenttyp | Zeitschriftenartikel |
| Peer Review | unbekannt |
| Sprache | Englisch |
| Titel | Neural activation during processing of aversive faces predicts treatment outcome in alcoholism |
| Autor(in); Institution |
Charlet, K.; Department of Psychiatry and Psychotherapy, Campus Mitte, Charité Universitätsmedizin Berlin, GERMANY
Schlagenhauf, F.; Department of Psychiatry and Psychotherapy, Campus Mitte, Charité Universitätsmedizin Berlin, GERMANY
Richter, A.; Central Institute of Mental Health, GERMANY
Naundor, K.; Department of Psychiatry and Psychotherapy, Campus Mitte, Charité Universitätsmedizin Berlin, GERMANY
Dornhof, L.; Department of Psychiatry and Psychotherapy, Campus Mitte, Charité Universitätsmedizin Berlin, GERMANY
Weinfurtner, Ch.; Department of Psychiatry and Psychotherapy, Campus Mitte, Charité Universitätsmedizin Berlin, GERMANY
König, F.; Department of Psychiatry and Psychotherapy, Campus Mitte, Charité Universitätsmedizin Berlin, GERMANY
Walaszek, Bernadeta; 8.1, Medizinische Messtechnik, PTB-Berlin
Schubert, Florian; 8.1, Medizinische Messtechnik, PTB-Berlin
Müller, Ch.; Department of Psychiatry and Psychotherapy, Campus Mitte, Charité Universitätsmedizin Berlin, GERMANY
Gutwinski, St.; Charité Department of Psychiatry and Psychotherapy, St Hedwig Krankenhaus, GERMANY
Seissinger, A:; Department of Medical Psychology, Zentrum für Nervenheilkunde, Universitätsklinikum Bonn, GERMANY
Schmitz, L.; Department of Medical Psychology, Zentrum für Nervenheilkunde, Universitätsklinikum Bonn, GERMANY
Walter, H.; Department of Medical Psychology, Zentrum für Nervenheilkunde, Universitätsklinikum Bonn, GERMANY
Beck, A.; Department of Psychiatry and Psychotherapy, Campus Mitte, Charité Universitätsmedizin Berlin, GERMANY
Gallinat, J.; Clinic for Psychiatry and Psychotherapy, St Hedwig-Krankenhaus, Charité University Medicine, Berlin, GERMANY
Kiefer, F.; Central Institute of Mental Health, GERMANY
Heinz, A.; Department of Psychiatry and Psychotherapy, Campus Mitte, Charité Universitätsmedizin Berlin, GERMANY
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| Quelle/Jahr | Addiction Biology: 19 (2014), 3, 439 - 451 |
| ISSN | 1355-6215 (PRINT) ; 1369-1600 (ONLINE) |
| DOI | |
| Verlag | Oxford: Wiley |
| Freie Schlagworte | Anger ; anterior cingulate cortex ; fear ; follow-up ; implicit emotional face processing ; relapse |
| Zusammenfassung | Neuropsychological studies reported decoding deficits of emotional facial expressions in alcohol-dependent patients, and imaging studies revealed reduced prefrontal and limbic activation during emotional face processing. However, it remains unclear whether this reduced neural activation is mediated by alcohol-associated volume reductions and whether it interacts with treatment outcome.We combined analyses of neural activation during an aversive face-cuecomparison task and local gray matter volumes (GM) using Biological Parametric Mapping in 33 detoxified alcoholdependent patients and 33 matched healthy controls. Alcoholics displayed reduced activation toward aversive faces–ceutral shapes in bilateral fusiform gyrus [FG; Brodmann areas (BA) 18/19], right middle frontal gyrus (BA46/47), right inferior parietal gyrus (BA7) and left cerebellum compared with controls,whichwere explained byGMdifferences (except for cerebellum). Enhanced functional activation in patients versus controls was found in left rostral anterior cingulate cortex (ACC) and medial frontal gyrus (BA10/11), even afterGMreduction control. IncreasedACC activation correlated significantly with less (previous) lifetime alcohol intake [Lifetime Drinking History (LDH)], longer abstinence and less subsequent binge drinking in patients. High LDH appear to impair treatment outcome via its neurotoxicity on ACC integrity. Thus, high activation of the rostral ACC elicited by affective faces appears to be a resilience factor predicting better treatment outcome. Although no group differences were found, increased FG activation correlated with patients’ higher LDH. Because high LDH correlated with worse task performance for facial stimuli in patients, elevated activation in the fusiform ‘face’ area may reflect inefficient compensatory activation. Therapeutic interventions (e.g. emotion evaluation training) may enable patients to cope with social stress and to decrease relapses after detoxification. |
Zitierung
Charlet, K., Schlagenhauf, F., Richter, A., Naundor, K., Dornhof, L., Weinfurtner, C., König, F., Walaszek, B., Schubert, F., Müller, C., Gutwinski, S., Seissinger, A., Schmitz, L., Walter, H., Beck, A., Gallinat, J., Kiefer, F., & Heinz, A. (2014). Neural activation during processing of aversive faces predicts treatment outcome in alcoholism. Addiction Biology, 19(3), 439–451. https://doi.org/10.1111/adb.12045