| Zugriffsnummer | 28653 |
| Dokumenttyp | Zeitschriftenartikel |
| Peer Review | mit Peer Review |
| Sprache | Englisch |
| Titel | Visualizing brain inflammation with a shingled-leg radio-frequency head probe for 19 F/1H MRI |
| Autor(in); Institution |
Waiczies, H.; Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrück Center for Molecular Medicine, Berlin, GERMANY
Lepore, S.; Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrück Center for Molecular Medicine, Berlin, GERMANY
Drechsler, S.; Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrück Center for Molecular Medicine, Berlin, GERMANY
Qadri, F.; Experimental and Clinical Research Center, a joint cooperation between the Charite' Medical Faculty and the Max Delbrück Center for Molecular Medicine, Berlin, GERMANY
Purfürst, B.; Electron Microscopy Core Facility, Max Delbrück Center for Molecular Medicine, Berlin, GERMANY
Sydow, K.; Peptide Lipid Interaction/Peptide Transport, Leibniz-Institut für Molekulare Pharmakologie (FMP), Berlin, GERMANY
Dathe, M.; Peptide Lipid Interaction/Peptide Transport, Leibniz-Institut für Molekulare Pharmakologie (FMP), Berlin, GERMANY
Kühne, André; 8.1, Medizinische Messtechnik, PTB-Berlin
Lindel, Tomasz; 8.1, Medizinische Messtechnik, PTB-Berlin
Hoffmann, Werner; 8.1, Medizinische Messtechnik, PTB-Berlin
Pohlmann, A.; Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrück Center for Molecular Medicine, Berlin, GERMANY
Niendorf, T.; Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrück Center for Molecular Medicine, Berlin, GERMANY
Waczies, S.; Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrück Center for Molecular Medicine, Berlin, GERMANY
|
| Quelle/Jahr | Scientific Reports: 3 (2013), 10 S. |
| Availability | [online only] |
| ISSN | 2045-2322 |
| DOI | |
| Verlag | London: Nature Publishing Group |
| Zusammenfassung | Magnetic resonance imaging (MRI) provides the opportunity of tracking cells in vivo. Major challenges in dissecting cells from the recipient tissue and signal sensitivity constraints albeit exist. In this study, we aimed to tackle these limitations in order to study inflammation in autoimmune encephalomyelitis. We constructed a very small dual-tunable radio frequency (RF) birdcage probe tailored for 19 F (fluorine) and 1H (proton) MR mouse neuroimaging. The novel design eliminated the need for extra electrical components on the probe structure and afforded a uniform B +1 -fieldas well as good SNR. We employed fluorescently-tagged 19 F nanoparticles and could study the dynamics of inflammatory cells between CNS and lymphatic system during development of encephalomyelitis, even within regions of the brain that are otherwise not easily visualized by conventional probes. 19 F/ 1H MR Neuroimaging will allow us to study the nature of immune cell infiltration during brain inflammation over an extensive period of time. |
| Kostenfreier Zugang | Open Access Gold |
| Rechteinformation | CC BY-NC-ND 3.0 ; Creative Commons Attribution NonCommercial NoDerivatives 3.0 License |
Zitierung
Waiczies, H., Lepore, S., Drechsler, S., Qadri, F., Purfürst, B., Sydow, K., Dathe, M., Kühne, A., Lindel, T., Hoffmann, W., Pohlmann, A., Niendorf, T., & Waczies, S. (2013). Visualizing brain inflammation with a shingled-leg radio-frequency head probe for ¹⁹ F/¹H MRI. Scientific Reports, 3, 10 S. https://doi.org/10.1038/srep01280