| Zugriffsnummer | 28513 |
| Dokumenttyp | Zeitschriftenartikel |
| Sprache | Englisch |
| Titel | On a darkfield signal generated by micrometer-sized calcifications in phase contrast mammography |
| Autor(in); Institution |
Michel, Thilo; Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen Centre for Astroparticle Physics (ECAP), Erlangen, GERMANY
Rieger, Jens; Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen Centre for Astroparticle Physics (ECAP), Erlangen, GERMANY
Anton, Gisela; Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen Centre for Astroparticle Physics (ECAP), Erlangen, GERMANY
Bayer, Florian; Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen Centre for Astroparticle Physics (ECAP), Erlangen, GERMANY
Beckmann, Matthias W.; Friedrich-Alexander-Universität Erlangen, Department of Gynecology and Obstetrics, University Hospital Erlangen, Erlangen, GERMANY
Durst, Jürgen; Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen Centre for Astroparticle Physics (ECAP), Erlangen, GERMANY
Fasching, Peter A.; Friedrich-Alexander-Universität Erlangen, Department of Gynecology and Obstetrics, University Hospital Erlangen, Erlangen, GERMANY; University of California, Division of Hematology-Oncology, David Geffen School of Medicine, Los Angeles, USA
Freudenberger, Jörg; Siemens AG Healthcare Sector, Erlangen, GERMANY
Haas, Wilhelm; Friedrich-Alexander-Universität Erlangen, Pattern Recognition Lab, Erlangen, GERMANY
Hartmann, Arndt; Friedrich-Alexander-Universität Erlangen, Department of Gynecology and Obstetrics, University Hospital Erlangen, Erlangen, GERMANY
Pelzer, Georg; Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen Centre for Astroparticle Physics (ECAP), Erlangen, GERMANY
Radicke, Marcus; Siemens AG Healthcare Sector, Erlangen, GERMANY
Rauh, Claudia; Friedrich-Alexander-Universität Erlangen, Department of Gynecology and Obstetrics, University Hospital Erlangen, Erlangen, GERMANY
Ritter, André; Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen Centre for Astroparticle Physics (ECAP), Erlangen, GERMANY
Sievers, Peter; 6.3, Strahlenschutzdosimetrie, PTB-Braunschweig; Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen Centre for Astroparticle Physics (ECAP), Erlangen, GERMANY
Schulz-Wendtland, Rüdiger; Friedrich-Alexander-Universität Erlangen, Institute of Diagnostic Radiology, University Hospital Erlangen,Erlangen, GERMANY
Uder, Michael; Friedrich-Alexander-Universität Erlangen, Institute of Diagnostic Radiology, University Hospital Erlangen,Erlangen, GERMANY
Wachter, David L.; Friedrich-Alexander-Universität Erlangen, Institute of Pathology, University Hospital Erlangen, Erlangen, GERMANY
Weber, Thomas; Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen Centre for Astroparticle Physics (ECAP), Erlangen, GERMANY
Weisser, Matthias; Friedr.-Alexander-Universität Erlangen, Erlangen, GERMANY
Wenkel, Evelyn; Friedrich-Alexander-Universität Erlangen, Institute of Diagnostic Radiology, University Hospital Erlangen,Erlangen, GERMANY
Zang, Andrea; Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen Centre for Astroparticle Physics (ECAP), Erlangen, GERMANY
|
| Quelle/Jahr | Physics in Medicine and Biology: 58 (2013), 8, 2713 - 2732 |
| ISSN | 0031-9155 (PRINT) ; 1361-6560 (ONLINE) |
| DOI | |
| Verlag | IOP |
| Klassifikationscode | PACS: 87.59.E- ; PACS: 87.59.bf ; PACS: 87.19.X- ; PACS: 87.57.C- |
| Zusammenfassung | We show that a distribution of micrometer-sized calcifications in the human breast which are not visible in clinical x-ray mammography at diagnostic dose levels can produce a significant dark-field signal in a grating-based x-ray phase-contrast imaging setup with a tungsten anode x-ray tube operated at 40 kVp. A breast specimen with invasive ductal carcinoma was investigated immediately after surgery by Talbot-Lau x-ray interferometry with a design energy of 25 keV. The sample contained two tumors which were visible in ultrasound and contrast-agent enhanced MRI but invisible in clinical x-ray mammography, in specimen radiography and in the attenuation images obtained with the Talbot-Lau interferometer. One of the tumors produced significant dark-field contrast with an exposure of 0.85 mGy air-kerma. Staining of histological slices revealed sparsely distributed grains of calcium phosphate with sizes varying between 1 and 40 μm in the region of this tumor. By combining the histological investigations with an x-ray wave-field simulation we demonstrate that a corresponding distribution of grains of calcium phosphate in the form of hydroxylapatite has the ability to produce a dark-field signal which would-to a substantial degree-explain the measured dark-field image. Thus we have found the appearance of new information (compared to attenuation and differential phase images) in the dark-field image. The second tumor in the same sample did not contain a significant fraction of these very fine calcification grains and was invisible in the dark-field image. We conclude that some tumors which are invisible in x-ray absorption mammography might be detected in the x-ray dark-field image at tolerable dose levels. |
Zitierung
Michel, T., Rieger, J., Anton, G., Bayer, F., Beckmann, M. W., Durst, J., Fasching, P. A., Freudenberger, J., Haas, W., Hartmann, A., Pelzer, G., Radicke, M., Rauh, C., Ritter, A., Sievers, P., Schulz-Wendtland, R., Uder, M., Wachter, D. L., Weber, T., Weisser, M., Wenkel, E., & Zang, A. (2013). On a darkfield signal generated by micrometer-sized calcifications in phase contrast mammography. Physics in Medicine and Biology, 58(8), 2713–2732. https://doi.org/10.1088/0031-9155/58/8/2713