| Zugriffsnummer | 28508 |
| Dokumenttyp | Zeitschriftenartikel |
| Peer Review | mit Peer Review |
| Sprache | Englisch |
| Titel | Non-contact time-resolved diffuse reflectance imaging at null source-detector separation |
| Autor(in); Institution |
Mazurenka, Mikhail; 8.3, Biomedizinische Optik, PTB-Berlin
Jelzow, Alexander; 8.3, Biomedizinische Optik, PTB-Berlin
Wabnitz, Heidrun; 8.3, Biomedizinische Optik, PTB-Berlin
Contini, D.; Dipartimento di Fisica, Politecnico di Milano, ITALY
Spinelli, L.; Istituto di Fotonica e Nanotecnologie, Consiglio Nazionale delle Ricerche, Milano, ITALY
Pifferi, A.; Dipartimento di Fisica, Politecnico di Milano, ITALY
Cubeddu, R.; Dipartimento di Fisica, Politecnico di Milano, ITALY
Dalla Mora, A.; Dipartimento di Fisica, Politecnico di Milano, ITALY
Tosi, A.; Dipartimento di Elettronica e Informazione, Politecnico di Milano, Milano, ITALY
Zappa, F.; Dipartimento di Elettronica e Informazione, Politecnico di Milano, Milano, ITALY
Macdonald, Rainer; 8.3, Biomedizinische Optik, PTB-Berlin
|
| Quelle/Jahr | Optics Express: 20 (2012), 1, 283 - 290 |
| ISSN | 1094-4087 (ONLINE) |
| DOI | |
| URL | |
| Verlag | Washington, DC: Soc. |
| Klassifikationscode | OCIS: 120.3890 ; OCIS: 170.3880 ; OCIS: 170.5280 ; OCIS: 170.6510 ; OCIS: 170.6920 |
| Freie Schlagworte | Photon migration ; Time-resolved imaging ; Medical and biological imaging ; Spectroscopy, tissue diagnostics ; Medical optics instrumentation |
| Zusammenfassung | We report results of the proof-of-principle tests of a novel noncontact tissue imaging system. The system utilizes a quasi-null sourcedetector separation approach for time-domain near-infrared spectroscopy, taking advantage of an innovative state-of-the-art fast-gated single photon counting detector. Measurements on phantoms demonstrate the feasibility of the non-contact approach for the detection of optically absorbing perturbations buried up to a few centimeters beneath the surface of a tissue-like turbid medium. The measured depth sensitivity and spatial resolution of the new system are close to the values predicted by Monte Carlo simulations for the inhomogeneous medium and an ideal fast-gated detector, thus proving the feasibility of the non-contact approach for high density diffuse reflectance measurements on tissue. Potential applications of the system are also discussed. |
| Kostenfreier Zugang | Open Access Gold |
Zitierung
Mazurenka, M., Jelzow, A., Wabnitz, H., Contini, D., Spinelli, L., Pifferi, A., Cubeddu, R., Dalla Mora, A., Tosi, A., Zappa, F., & Macdonald, R. (2012). Non-contact time-resolved diffuse reflectance imaging at null source-detector separation. Optics Express, 20(1), 283–290. https://doi.org/10.1364/oe.20.000283