| Zugriffsnummer | 28405 |
| Dokumenttyp | Konferenzartikel |
| Sprache | Englisch |
| Titel | Functional MR spectroscopy reveals neurotransmitter changes in frontal cortex during Stroop task |
| Autor(in); Institution |
Schubert, Florian; 8.1, Medizinische Messtechnik, PTB-Berlin
Wenger, E.; Center for Lifespan Psychology, Max Planck Institute for Human Development (MPI für Bildungsforschung), Berlin, GERMANY
Mekle, Ralf; 8.1, Medizinische Messtechnik, PTB-Berlin
Ittermann, Bernd; 8.1, Medizinische Messtechnik, PTB-Berlin
Lindenberger, U.; Center for Lifespan Psychology, Max Planck Institute for Human Development (MPI für Bildungsforschung), Berlin, GERMANY
Gallinat, J.; Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, GERMANY
Kühn, S.; Center for Lifespan Psychology, Max Planck Institute for Human Development (MPI für Bildungsforschung), Berlin, GERMANY
|
| Quelle/Jahr | ESMRMB 2012 Congress, October 4–6, Lisbon/PT: Book of Abstracts ; in: Magnetic Resonance Materials in Physics, Biology and Medicine: 25 (2012), Suppl. 1, 328 |
| ISSN | 0968-5243 (PRINT) ; 1352-8661 (ONLINE) |
| DOI | |
| Verlag | Heidelberg: Springer |
| Konferenzangaben | European Society for Magnetic Resonance in Biology and Medicine (ESMRMB), 29th Annual Scientific Meeting, Lissabon, 04-06, October, 2012, Portugal |
| Zusammenfassung | Purpose/Introduction: Measuring conflict processing, cognitive flexibility and attention [1], the Stroop test is a valuable tool for the study of brain disorders. Stroop activation has consistently been found in the anterior cingulate [2]. To elucidate whether the activation during this conflict-inducing paradigm is associated with neurotransmitter changes the spin echo full intensity acquired localized (SPECIAL) MRS technique [3] was used at 3T to acquire MRS data during neuronal stimulation. Subjects and Methods: Scans were conducted on a 3T Verio (Siemens) using a 32 channel receive-only head coil. Eighteen healthy volunteers (11 f, 25±1.7 years) underwent both an fMRI and an MRS session, while completing a manual version of the Stroop task. Functional images were collected using EPI (TR=2s, TE=30ms, matrix 64×64, FOV=224mm, flip angle 80º, slice thickness 3.5mm, 35 slices aligned with the AC-PC line). fMRI data were analyzed using SPM8. For MRS, all first- and second-order shims were adjusted using FAST(EST)MAP. SPECIAL spectra (TR=3s, TE=8.5ms, NA=256) were acquired at rest (off1), during (on) and after Stroop task (off2), from a voxel of 25x35x20mm3 placed on the region of maximum activation. LCModel was used for metabolite quantification, applying the unsuppressed water scan for referencing. Using repeated measures ANOVA with the factor time (on and off2 vs. off1) variations of concentration over time were explored. Results: CRLBs from LCModel fits for GABA, glutamate and glutamine were well below 20% for all spectra indicating high spectral quality. Significant effects of time were observed for the mean GABA, glutamate and glutamine levels, the two former increasing and then dropping back (p=0.019; p=0.017, respectively), the latter increasing (p=0.002). In contrast, total creatine did not show a significant time effect (p=0.372). Task-based GABA increase was positively correlated with the BOLD percent signal change difference of the incongruent–congruent condition within the spectroscopic voxel (r=0.524, p=0.026). Discussion/Conclusion: Both the inhibitory and the excitatory neurotransmitters GABA and glutamate with ist complement glutamine appear to be modulated during execution of the Stroop paradigm. The most dramatic changes are those on GABA which are in turn associated with functional parameters, indicating an increased need for recruitment of inhibitory neural circuits. The SPECIAL sequence at high B0 appears promising for application in fMRS. References: 1. Howieson D B et al, 2004, in: Neuropsychological assessment. Oxford University Press,3365–367. 2. Carter CS et al, Cogn Affect Behav Neurosci 2007,7:367–79. 3. Mlynarik V et al, MRM 2006,56:965-70. |
Zitierung
Schubert, F., Wenger, E., Mekle, R., Ittermann, B., Lindenberger, U., Gallinat, J., & Kühn, S. (2012). Functional MR spectroscopy reveals neurotransmitter changes in frontal cortex during Stroop task. European Society for Magnetic Resonance in Biology and Medicine (ESMRMB), 29th Annual Scientific Meeting, Lissabon, 04-06, October, 2012, Portugal. https://doi.org/10.1007/s10334-012-0323-x