| Zugriffsnummer | 27459 |
| Dokumenttyp | Konferenzartikel |
| Sprache | Englisch |
| Titel | Using short TE 1H MRS methodology for the reliable detection of GABA in the human amygdala [poster] |
| Autor(in); Institution |
Mekle, Ralf; 8.1, Medizinische Messtechnik, PTB-Berlin
Kühn, Simone; Department of Experimental Psychology and Ghent Institute for Functional and Metabolic Imaging, Ghent University, Ghent, BELGIUM
Lindel, Tomasz Dawid; 8.1, Medizinische Messtechnik, PTB-Berlin
Schubert, Florian; 8.1, Medizinische Messtechnik, PTB-Berlin
Gallinat, Jürgen; Clinic for Psychiatry and Psychotherapy, Charité University Medicine, Berlin, GERMANY
Ittermann, Bernd; 8.1, Medizinische Messtechnik, PTB-Berlin
|
| Quelle/Jahr | ISMRM 20th annual meeting & exhibition: 5-11 May 2012; Melbourne, Australia: 20 (2012), 4383 |
| Availability | [CD-ROM] ; file name: 4383.pdf |
| ISSN | 1545-4428 |
| Verlag | Berkeley, Calif.: ISMRM |
| Konferenzangaben | ISMRM 20th Annual Meeting & Exhibition, Melbourne, 05-11, May, 2012, Australia |
| Freie Schlagworte | 3T; metabolite detection ; amygdala ; magnetic resonance spectroscopy |
| Zusammenfassung | The tiny amygdala is believed to a play central role in conditioning, i.e. in the expression of fear and anxiety, which is controlled by inhibitory GABA (γ-aminobutric acid)-ergic circuits. Measurement of GABA levels within the amygdala would allow to explore the neurochemical basis for conditioning and associated pathologies. However, performing MRS in this region is challenging due to its small size and testing B0 and B1 conditions. In this study, short TE 1H MR methodology using the SPECIAL technique was applied to overcome these limitations. GABA was reliably detected (CRLBs(20%) in N=8 volunteers, and slightly elevated concentrations were found. |
Zitierung
Mekle, R., Kühn, S., Lindel, T. D., Schubert, F., Gallinat, J., & Ittermann, B. (2012). Using short TE ¹H MRS methodology for the reliable detection of GABA in the human amygdala [poster]. ISMRM 20th Annual Meeting & Exhibition, Melbourne, 05-11, May, 2012, Australia.