| Zugriffsnummer | 26940 |
| Dokumenttyp | Zeitschriftenartikel |
| Peer Review | mit Peer Review |
| Sprache | Englisch |
| Titel | Prefrontal cortex glutamate and extraversion |
| Autor(in); Institution |
Grimm, S.; Cluster of Excellence 'Languages of Emotion', Freie Universität Berlin, Berlin, GERMANY
Schubert, Florian; 8.1, Medizinische Messtechnik, PTB-Berlin
Jädke, M.; Cluster of Excellence 'Languages of Emotion', Freie Universität Berlin, Berlin, GERMANY
Gallinat, J.; Charité University Medicine, Campus Mitte, St Hedwig Krankenhaus, Clinic for Psychiatry and Psychotherapy, Berlin, GERMANY
Bajbouj, M.; Cluster of Excellence 'Languages of Emotion', Freie Universität Berlin, Berlin, GERMANY
|
| Quelle/Jahr | Social Cognitive and Affective Neuroscience (SCAN): 7 (2012), 7, 811 - 818 |
| ISSN | 1749-5016 (PRINT) ; 1749-5024 (ONLINE) |
| DOI | |
| Verlag | Oxford: Oxford Univ. Press |
| Freie Schlagworte | 1H-MRS ; glutamate ; prefrontal cortex ; personality ; extraversion |
| Zusammenfassung | Extraversion is considered one of the core traits of personality. Low extraversion has been associated with increased vulnerability to affective and anxiety disorders. Brain imaging studies have linked extraversion, approach behaviour and the production of positive emotional states to the dorsolateral prefrontal cortex (DLPFC) and glutamatergic neurotransmission. However, the relationship between extraversion and glutamate in the DLPFC has not been investigated so far. In order to address this issue, absolute glutamate concentrations in the DLPFC and the visual cortex as a control region were measured by 3-Tesla proton magnetic resonance spectroscopy (1H-MRS) in 29 subjects with high and low extraversion. We found increased glutamate levels in the DLPFC of introverts as compared with extraverts. The increased glutamate concentration was specific for the DLPFC and negatively associated with state anxiety. Although preliminary, results indicate altered top-down control of DLPFC due to reduced glutamate concentration as a function of extraversion. Glutamate measurement with 1H-MRS may facilitate the understanding of biological underpinnings of personality traits and psychiatric diseases associated with dysfunctions in approach behaviour and the production of positive emotional states. |
| Kostenfreier Zugang | Open Access Gold |
| Rechteinformation | CC BY-NC 3.0 ; Creative Commons Attribution NonCommercial 3.0 License |