| Zugriffsnummer | 26484 |
| Dokumenttyp | Zeitschriftenartikel |
| Sprache | Englisch |
| Titel | Cerebral perfusion in acute stroke monitored by time-domain near-infrared reflectometry |
| Autor(in); Institution |
Steinkellner, Oliver; 8.3, Biomedizinische Optik, PTB-Berlin
Wabnitz, Heidrun; 8.3, Biomedizinische Optik, PTB-Berlin
Jelzow, Alexander; 8.3, Biomedizinische Optik, PTB-Berlin
Macdonald, Rainer; 8.3, Biomedizinische Optik, PTB-Berlin
Gruber, Clemens; Klinik für Neurologie and Center for Stroke Research Berlin, Charité - Universitätsmedizin Berlin, GERMANY
Steinbrink, Jens; Klinik für Neurologie and Center for Stroke Research Berlin, Charité - Universitätsmedizin Berlin, GERMANY
Obrig, Hellmuth; Klinik für Kognitive Neurologie, Universitätsklinik Leipzig, GERMANY
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| Quelle/Jahr | Biocybernetics and Biomedical Engineering: 32 (2012), 1, 3 - 16 |
| ISSN | 0208-5216 |
| Verlag | Warszawa: Panstwowe Wydawn. Naukowe |
| Freie Schlagworte | Light propagation in tissues ; Time-resolved imaging ; Optical bolus tracking |
| Zusammenfassung | Though potentially relevant for the monitoring of acute stroke, even specialized stroke units do not provide continuous methods to determine cerebral perfusion at the bedside. We present patient measurements on cerebral perfusion in ischemic stroke applying optical bolus tracking. To this end, our portable time-domain near-infrared reflectometer has been optimized and technically approved for clinical studies by a notified body. We used data analysis based on statistical moments of measured time-of-flight distributions of photons. Selective sensitivity to deep absorption changes and a suitable representation of cerebral signals is associated with the suppression of movement artifacts in severely affected patients. The proposed technique offers the unique possibility for a frequently repeatable monitoring of cerebral blood flow during acute and subacute cerebral ischemia directly at the bedside. |
