| Zugriffsnummer | 26031 |
| Dokumenttyp | Zeitschriftenartikel |
| Peer Review | mit Peer Review |
| Sprache | Englisch |
| Titel | Metabolic changes in the visual cortex are linked to retinal nerve fiber layer thinning in multiple sclerosis |
| Autor(in); Institution |
Pfüller, C.F.; NeuroCure Clinical Research Center, Charite' Universitätsmedizin Berlin, GERMANY
Brandt, A.; NeuroCure Clinical Research Center, Charite' Universitätsmedizin Berlin, GERMANY
Schubert, Florian; 8.1, Medizinische Messtechnik, PTB-Berlin
Bock, M.; NeuroCure Clinical Research Center, Charite' Universitätsmedizin Berlin, GERMANY
Walaszek, Bernadeta; 8.1, Medizinische Messtechnik, PTB-Berlin
Waiczies, Helmar; 8.1, Medizinische Messtechnik, PTB-Berlin
Schwenteck, Thomas; 8.1, Medizinische Messtechnik, PTB-Berlin
Dörr, J.; NeuroCure Clinical Research Center, Charite' Universitätsmedizin Berlin, GERMANY
Bellmann-Strobl, J.; Experimental and Clinical Research Center, Charite' Universitätsmedizin Berlin and Max-Delbrueck-Center for Molecular Medicine, Berlin, GERMANY
Mohr, C.; Institute of Neuroradiology, University Lübeck, GERMANY
Weinges-Evers, N.; NeuroCure Clinical Research Center, Charite' Universitätsmedizin Berlin, GERMANY
Ittermann, Bernd; 8.1, Medizinische Messtechnik, PTB-Berlin
Würfel, J.T.; NeuroCure Clinical Research Center, Charite' Universitätsmedizin Berlin, GERMANY
Paul, F.; NeuroCure Clinical Research Center, Charite' Universitätsmedizin Berlin, GERMANY
|
| Quelle/Jahr | PLoS one: 6 (2011), 4, 7 S. |
| Artikelnummer | e18019 |
| ISSN | 1932-6203 |
| DOI | |
| Verlag | Lawrence: Public Library of Science |
| Zusammenfassung | Objective: To investigate the damage to the retinal nerve fiber layer as part of the anterior visual pathway as well as an impairment of the neuronal and axonal integrity in the visual cortex as part of the posterior visual pathway with complementary neuroimaging techniques, and to correlate our results to patients’ clinical symptoms concerning the visual pathway. Design, Subjects and Methods: Survey of 86 patients with relapsing-remitting multiple sclerosis that were subjected to retinal nerve fiber layer thickness (RNFLT) measurement by optical coherence tomography, to a routine MRI scan including the calculation of the brain parenchymal fraction (BPF), and to magnetic resonance spectroscopy at 3 tesla, quantifying Nacetyl aspartate (NAA) concentrations in the visual cortex and normal-appearing white matter. Results: RNFLT correlated significantly with BPF and visual cortex NAA, but not with normal-appearing white matter NAA. This was connected with the patients’ history of a previous optic neuritis. In a combined model, both BPF and visual cortex NAA were independently associated with RNFLT. Conclusions: Our data suggest the existence of functional pathway-specific damage patterns exceeding global neurodegeneration. They suggest a strong interrelationship between damage to the anterior and the posterior visual pathway. |
| Kostenfreier Zugang | Open Access Gold |
| Rechteinformation | Creative Commons Attribution License |
Zitierung
Pfüller, C., Brandt, A., Schubert, F., Bock, M., Walaszek, B., Waiczies, H., Schwenteck, T., Dörr, J., Bellmann-Strobl, J., Mohr, C., Weinges-Evers, N., Ittermann, B., Würfel, J., & Paul, F. (2011). Metabolic changes in the visual cortex are linked to retinal nerve fiber layer thinning in multiple sclerosis. PLoS one, 6(4), 7 S. https://doi.org/10.1371/journal.pone.0018019