| Zugriffsnummer | 25970 |
| Dokumenttyp | Konferenzartikel in Zeitschrift |
| Sprache | Englisch |
| Titel | Cancer therapy with drug loaded magnetic nanoparticles-magnetic drug targeting |
| Autor(in); Institution |
Alexiou, C.; Department of Oto-rhino-laryngology, Head and Neck Surgery, University Hospital Erlangen, Section for Experimental Oncology and Nanomedicine at the Else Kröner-Fresenius-Stiftung-Professorship, Erlangen, GERMANY
Tietze, R.; Department of Oto-rhino-laryngology, Head and Neck Surgery, University Hospital Erlangen, Section for Experimental Oncology and Nanomedicine at the Else Kröner-Fresenius-Stiftung-Professorship, Erlangen, GERMANY
Schreiber, E.; Department of Oto-rhino-laryngology, Head and Neck Surgery, University Hospital Erlangen, Section for Experimental Oncology and Nanomedicine at the Else Kröner-Fresenius-Stiftung-Professorship, Erlangen, GERMANY
Jurgons, R.; Franz Penzoldt Center, University Hospital Erlangen, Erlangen, GERMANY
Richter, Heike; 8.2, Biosignale, PTB-Berlin
Trahms, Lutz; 8.2, Biosignale, PTB-Berlin
Rahn, H.; TU Dresden, Chair of Magnetofluiddynamics, Dresden, GERMANY
Odenbach, S; TU Dresden, Chair of Magnetofluiddynamics, Dresden, GERMANY
Lyer, S.; Department of Oto-rhino-laryngology, Head and Neck Surgery, University Hospital Erlangen, Section for Experimental Oncology and Nanomedicine at the Else Kröner-Fresenius-Stiftung-Professorship, Erlangen, GERMANY
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| Quelle/Jahr | Proceedings of 12th International Conference on Magnetic Fluid. Journal of Magnetism and Magnetic Materials: 323 (2010), 10, 1404 - 1407 |
| ISSN | 0304-8853 (PRINT) |
| DOI | |
| Verlag | Amsterdam: Elsevier |
| Konferenzangaben | 12th International Conference on Magnetic Fluid, Sendai, 1-5, August, 2010, Japan |
| Freie Schlagworte | Cancer treatment ; Nanoparticle ; Local chemotherapy |
| Zusammenfassung | The aim of magnetic drug targeting (MDT) in cancer therapy is to concentrate chemotherapeutics to a tumor region while simultaneously the overall dose is reduced. This can be achieved with coated superparamagnetic nanoparticles bound to a chemotherapeutic agent. These particles are applied intra arterially close to the tumor region and focused to the tumor by a strong external magnetic field. The interaction of the particles with the field gradient leads to an accumulation in the region of interest (i.e. tumor). The particle enrichment and thereby the drug-load in the tumor duringMDT has been proven by several analytical and imagingmethods. Moreover, in pilot studies we investigated in an experimental in vivo tumor model the effectiveness of this approach. Complete tumor regressions without any negative side effects could be observed. |
Zitierung
Alexiou, C., Tietze, R., Schreiber, E., Jurgons, R., Richter, H., Trahms, L., Rahn, H., Odenbach, S., & Lyer, S. (2010). Cancer therapy with drug loaded magnetic nanoparticles-magnetic drug targeting. Journal of Magnetism and Magnetic Materials, 323(10), 1404–1407. https://doi.org/10.1016/j.jmmm.2010.11.059