| Zugriffsnummer | 25918 |
| Dokumenttyp | Zeitschriftenartikel |
| Sprache | Englisch |
| Titel | Oscillations in the lateral pressure of lipid monolayers induced by nonlinear chemical dynamics of the second messengers MARCKS and Protein Kinase C |
| Autor(in); Institution |
Alonso, Sergio; 8.4, Mathematische Modellierung und Datenanalyse, PTB-Berlin
Dietrich, Undine; University of Leipzig, Division of Soft Matter Physics, Leipzig, GERMANY
Händel, Chris; University of Leipzig, Division of Soft Matter Physics, Leipzig, GERMANY
Käs, Josef A.; University of Leipzig, Division of Soft Matter Physics, Leipzig, GERMANY
Bär, Markus; 8.4, Mathematische Modellierung und Datenanalyse, PTB-Berlin
|
| Quelle/Jahr | Biophysical Journal: 100 (2011), 4, 939 - 947 |
| ISSN | 0006-3495 (PRINT) ; 1542-0086 (ONLINE) |
| DOI | |
| Verlag | Bethesda, Md.: Biophysical Society |
| Freie Schlagworte | Reaction-diffusion models ; MARCKS proteins ; Protein Kinase ; Oscillations ; Membrane proteins ; Langmuir monolayer |
| Zusammenfassung | The binding of the MARCKS peptide to the lipid monolayer containing PIP2 increases the lateral pressure of the monolayer. The unbinding dynamics modulated by protein kinase C leads to oscillations in lateral pressure of lipid monolayers. These periodic dynamics can be attributed to changes in the crystalline lipid domain size. We have developed a mathematical model to explain these observations based on the changes in the physical structure of the monolayer by the translocation of MARCKS peptide. The model indicates that changes in lipid domain size drives these oscillations. The model is extended to an open system that sustains chemical oscillations. |
Zitierung
Alonso, S., Dietrich, U., Händel, C., Käs, J. A., & Bär, M. (2011). Oscillations in the lateral pressure of lipid monolayers induced by nonlinear chemical dynamics of the second messengers MARCKS and Protein Kinase C. Biophysical Journal, 100(4), 939–947. https://doi.org/10.1016/j.bpj.2010.12.3702