| Zugriffsnummer | 25883 |
| Dokumenttyp | Konferenzartikel |
| Sprache | Englisch |
| Titel | Multichannel magnetorelaxometry in vivo monitoring of magnetic nanoparticle quantity for thermal ablation studies |
| Autor(in); Institution |
Richter, Heike; 8.2, Biosignale, PTB-Berlin
Kettering, M.; Institute of Diagnostic and Interventional Radiology, Jena University Hospital-Friedrich Schiller University Jena, Jena, GERMANY
Wiekhorst, Frank; 8.2, Biosignale, PTB-Berlin
Kosch, Olaf; 8.1, Medizinische Messtechnik, PTB-Berlin
Hilger, I.; Institute of Diagnostic and Interventional Radiology, Jena University Hospital-Friedrich Schiller University Jena, Jena, GERMANY
Trahms, Lutz; 8.2, Biosignale, PTB-Berlin
|
| Quelle/Jahr | 8th International Conference on the Scientific and Clinical Applications of Magnetic Carriers, Rostock, Germany, 25-29 May 2010:(2010), 255 - 260 |
| Schriftenreihe | AIP conference proceedings: 1311 |
| Herausgeber(in) |
Häfeli, Urs
|
| ISBN | 978-0-7354-0866-1 |
| DOI | |
| URL | |
| Verlag | Melville, NY: AIP |
| Konferenzangaben | 8th International Conference on the Scientific and Clinical Applications of Magnetic Carriers, Rostock, 25-29, May, 2010, Germany |
| Klassifikationscode | PACS: 78.67.Bf ; PACS: 73.20.Fz ; PACS: 85.25.Dq ; PACS: 75.20.Hr |
| Freie Schlagworte | nanostructured materials ; localised states ; SQUID magnetometers ; magnetic moments |
| Zusammenfassung | To inactivate cancer cells with minimal side-effects to the normal tissue, cancer therapy as magnetic thermal ablation utilizes superparamagnetic iron oxide nanoparticles (MNP) injected into the tumor. When exposed to an externally applied alternating magnetic field MNP generate heat, which deactivates cellular processes or even generates lethal thermal doses. Hence, the intratumoral quantity of MNP needs to be thoroughly controlled to govern adequate heat production in the carcinoma region. Here, we investigate the capability of multichannel magnetorelaxometry (MRX) for quantitative measurement of MNP accumulation in the tumor region performed in vivo on a carcinoma mouse, and moreover, the feasibility of quantitative long-term monitoring of MNP amount in a conscious, freely moving mouse. |
Zitierung
Richter, H., Kettering, M., Wiekhorst, F., Kosch, O., Hilger, I., & Trahms, L. (2010). Multichannel magnetorelaxometry in vivo monitoring of magnetic nanoparticle quantity for thermal ablation studies. 8th International Conference on the Scientific and Clinical Applications of Magnetic Carriers, Rostock, 25-29, May, 2010, Germany. https://doi.org/10.1063/1.3530021