| Zugriffsnummer | 25630 |
| Dokumenttyp | Konferenzartikel in Zeitschrift |
| Peer Review | unbekannt |
| Sprache | Englisch |
| Titel | Effect of a static magnetic field on nanodosimetric quantities in a DNA volume |
| Autor(in); Institution |
Lazarakis, Peter; 6.6, Grundlagen der Dosimetrie, PTB-Braunschweig
Bug, Marion U.; 6.6, Grundlagen der Dosimetrie, PTB-Braunschweig
Gargioni, Elisabetta; Universitätsklinikum Hamburg-Eppendorf (UKE), Hamburg, GERMANY
Guatelli, Susanna; University of Wollongong, Centre for Medical Radiation Physics (CMRP), Wollongong, NSW, AUSTRALIA
Incerti, Sebastien; Centre d'Etudes Nucléaires de Bordeaux-Gradignan (CENBG), IN2P3/CNRS, Bordeaux University, Gradignan Cedex, FRANCE
Rabus, Hans; 6.6, Grundlagen der Dosimetrie, PTB-Braunschweig
Rosenfeld, Anatoly B.; University of Wollongong, Centre for Medical Radiation Physics (CMRP), Wollongong, NSW, AUSTRALIA
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| Quelle/Jahr | Proceedings from the International Workshop in Monte Carlo Computational Methods in Radiation Track Simulation and Applications in Physical, Biological, and Medical Sciences (MC 2010). International Journal of Radiation Biology: 88 (2012), 1/2, 183 - 188 |
| ISSN | 0955-3002 |
| DOI | |
| URL | |
| Verlag | Abingdon: Informa Healthcare |
| Konferenzangaben | Monte Carlo 2010, Stockholm, 09-12, November, 2010, Sweden |
| Freie Schlagworte | Nanodosimetry ; Monte Carlo ; Radiotherapy ; Magnetic field ; Secondary electrons ; GEANT4 ; Cluster size |
| Zusammenfassung | Objective: With the advent of MRI guided radiation therapy it is becoming increasingly important to consider the potential influence of a magnetic field on ionising radiation. This paper aims to study the effect of a magnetic field on the track structure of radiation to determine if the biological effectiveness may be altered. Methods: Using the Geant4-DNA Monte Carlo simulation toolkit, nanodosimetric track structure parameters were calculated for electrons, protons and alpha particles moving in transverse magnetic fields up to 10 Tesla. Applying the model proposed by Garty et al. the track structure parameters were used to derive the probability of producing a double strand break (DSB). Results: For all primary particles and energy ranges simulated the application of a magnetic field was shown to have no significant effect (within statistical uncertainty limits) on the parameters characterising radiation track structure or the probability of producing a DSB. Conclusions: Within statistical uncertainty, the implementation of a magnetic field had no significant effect on the parameters characterising radiation track structure or the probability of producing a DSB. This implies that if the presence of a magnetic field were to induce a change in the biological effectiveness of radiation, the effect would not be physical. |
Zitierung
Lazarakis, P., Bug, M. U., Gargioni, E., Guatelli, S., Incerti, S., Rabus, H., & Rosenfeld, A. B. (2012). Effect of a static magnetic field on nanodosimetric quantities in a DNA volume. International Journal of Radiation Biology, 88(1/2), 183–188. https://doi.org/10.3109/09553002.2011.641436