| Zugriffsnummer | 25628 |
| Dokumenttyp | Konferenzartikel in Zeitschrift |
| Peer Review | unbekannt |
| Sprache | Englisch |
| Titel | Simulation of ionization clusters formed in nanometric volumes of the desoxyribose-substitute tetrahydrofuran |
| Autor(in); Institution |
Bug, Marion U.; 6.6, Grundlagen der Dosimetrie, PTB-Braunschweig
Baek, Woon Yong; 6.6, Grundlagen der Dosimetrie, PTB-Braunschweig
Rabus, Hans; 6.6, Grundlagen der Dosimetrie, PTB-Braunschweig
|
| Quelle/Jahr | Proceedings from the International Workshop in Monte Carlo Computational Methods in Radiation Track Simulation and Applications in Physical, Biological, and Medical Sciences (MC 2010). International Journal of Radiation Biology: 88 (2012), 1/2, 137 - 142 |
| ISSN | 0955-3002 (PRINT) ; 1362-3095 (ONLINE) |
| DOI | |
| Verlag | Abingdon: Informa Healthcare |
| Konferenzangaben | Monte Carlo 2010, Stockholm, 09-12, November, 2010, Sweden |
| Freie Schlagworte | Nanodosimetry ; Monte Carlo simulations ; Cross section ; Tetrahydrofuran ; Double strand break ; biomolecule |
| Zusammenfassung | Purpose: To investigate the implications of using interaction cross sections of liquid water for the target volume when studying radiation action at the DNA level by particle track structure simulations. Materials and methods: Absolute interaction cross sections for low energy electrons were measured for tetrahydrofuran (THF), which is a substitute for deoxyribose. From these data a complete interaction cross section data set was derived and integrated in our track structure Monte Carlo code. Simulations of electron track structure in THF and water were performed and ionisation cluster size distributions in nanometric target volumes were determined. From these a nanodosimetric estimate for the probability to produce a double strand break was derived. Results: Ionisation cluster size distributions were found to be shifted towards smaller values for a THF-filled target as compared to a water-filled one. For all electron energies the nanodosimetric estimates for double strand break probability in the THF-filled target have lower values than for a target of liquid water. Conclusion: The results indicate that simulations based on cross sections of water would overestimate the initial radiation damage to the DNA. |
