| Zugriffsnummer | 24741 |
| Dokumenttyp | Konferenzartikel |
| Sprache | Englisch |
| Titel | Pressure dependent signal enhancement in hyper-CEST |
| Autor(in); Institution |
Kilian, Wolfgang; 8.1, Medizinische Messtechnik, PTB-Berlin
Mitschang, Lorenz; 8.1, Medizinische Messtechnik, PTB-Berlin
Freund, C.; Leibnizinstitut für Molekulare Pharmakologie, Berlin, GERMANY
Schlundt, A.; Leibnizinstitut für Molekulare Pharmakologie, Berlin, GERMANY
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| Quelle/Jahr | Proceedings International Society for Magnetic Resonance in Medicine: 18 (2010), 2580 |
| Availability | [CD-ROM] ; file name: 2580_1305.pdf |
| ISSN | 1545-4428 |
| Konferenzangaben | ISMRM-ESMRMB Joint Annual Meeting ; ISMRM 18th Scientific Meeting, Stockholm, 01-07, May, 2010, Schweden |
| Zusammenfassung | The so called hyper-CEST method promises tremendous potential on molecule-specific MR imaging using hyperpolarized 129Xe caged in functionalized cryptophane cages. Here we present a model which allows for an optimization of the hyper-CEST sensitivity in biosensor applications, by variation of the xenon concentration in the solution. To evaluate the model we have performed hyper-CEST measurements on samples with 5 M and 0.5 M biosensor concentrations and varied the dissolved xenon concentration. This comparison shows that 50 nM biosensor concentrations should be detectable within a volume of 1 ml with high sensitivity. |
