| Zugriffsnummer | 24447 |
| Dokumenttyp | Zeitschriftenartikel |
| Sprache | Englisch |
| Titel | A nanodosimetric model of radiation-induced clustered DNA damage yields |
| Autor(in); Institution |
Garty, G.; Weizmann Institute of Science, Department of Particle Physics, Rehovot, ISRAEL
Schulte, R.; Loma Linda University Medical Center, Department of Radiation Medicine, Loma Linda, CA, USA
Shchemelinin, S.; Weizmann Institute of Science, Department of Particle Physics, Rehovot, ISRAEL
Leloup, C.; Weizmann Institute of Science, Department of Particle Physics, Rehovot, ISRAEL
Assaf, G.; Weizmann Institute of Science, Department of Particle Physics, Rehovot, ISRAEL
Breskin, A.; Weizmann Institute of Science, Department of Particle Physics, Rehovot, ISRAEL
Chechik, R.; Weizmann Institute of Science, Department of Particle Physics, Rehovot, ISRAEL
Bashkirov, V.; Loma Linda University Medical Center, Department of Radiation Medicine, Loma Linda, CA, USA
Milligan, J.; University of California at San Diego, Department of Radiology, La Jolla, CA, USA
Großwendt, Bernd; 6.6, Grundlagen der Dosimetrie, PTB-Braunschweig; PTB-Braunschweig, retired staff
|
| Quelle/Jahr | Physics in Medicine and Biology: 55 (2010), 3, 761 - 781 |
| ISSN | 0031-9155 |
| DOI | |
| URL | |
| Verlag | Bristol: IOP Publishing |
| Klassifikationscode | PACS: 87.56.Da ; PACS: 87.53.Bn ; PACS: 87.15.M ; PACS: 87.15.B ; PACS: 87.14.G ; PACS: 87.53.-j |
| Freie Schlagworte | Nanodosimetry ; DNA damage ; Monte Carlo track structure |
| Zusammenfassung | We present a nanodosimetric model for predicting the yield of double strand breaks (DSBs) and non-DSB clustered damages induced in irradiated DNA. The model uses experimental ionization cluster size distributions measured in a gas model by an ion counting nanodosimeter or, alternatively, distributions simulated by a Monte Carlo track structure code developed to simulate the nanodosimeter. The model is based on a straightforward combinatorial approach translating ionizations, as measured or simulated in a sensitive gas volume, to lesions in a DNA segment of one-two helical turns considered equivalent to the sensitive volume of the nanodosimeter. The two model parameters, corresponding to the probability that a single ion detected by the nanodosimeter corresponds to a single strand break or a single lesion (strand break or base damage) in the equivalent DNA segment, were tuned by fitting the model-predicted yields to previously measured double-strand break and double-strand lesion yields in plasmid DNA irradiated with protons and helium nuclei. Model predictions were also compared to both yield data simulated by the PARTRAC code for protons of a wide range of different energies and experimental DSB and non-DSB clustered DNA damage yield data from the literature. The applicability and limitations of this model in predicting the LET dependence of clustered DNA damage yields are discussed. |
Zitierung
Garty, G., Schulte, R., Shchemelinin, S., Leloup, C., Assaf, G., Breskin, A., Chechik, R., Bashkirov, V., Milligan, J., & Großwendt, B. (2010). A nanodosimetric model of radiation-induced clustered DNA damage yields. Physics in Medicine and Biology, 55(3), 761–781. https://doi.org/10.1088/0031-9155/55/3/015