| Zugriffsnummer | 24360 |
| Dokumenttyp | Zeitschriftenartikel |
| Peer Review | unbekannt |
| Sprache | Englisch |
| Titel | Experimental and theoretical ventricular electrograms and their relation to electrophysiological gradients in the adult rat heart |
| Autor(in); Institution |
Weber dos Santos, Rodrigo; Department of Computer Science, Univ. Federal de Juiz de Fora, BRAZIL
Nygren, Anders; Department of Physiology and Biophysics, Centre for Bioengineering Research and Education, Department of Electrical and Computer Engineering, University of Calgary, Calgary, Alberta, CANADA
Campos, Fernando Otaviano; Department of Computer Science, Univ. Federal de Juiz de Fora, BRAZIL
Koch, Hans; 8, Medizinphysik und metrologische Informationstechnik, PTB-Berlin
Giles, Wayne; Whitaker Institute of Biomedical Engineering, University of California, USA
|
| Quelle/Jahr | American Journal of Physiology: Heart and Circulatory Physiology: 297 (2009), 4, H1521 - H1534 |
| ISSN | 0363-6135 (PRINT) ; 1522-1539 (ONLINE) |
| DOI | |
| Verlag | Bethesda, Md.: American Physiological Society |
| Freie Schlagworte | cardiac electrophysiology ; electrocardiogram ; potassium currents ; mathematical models ; voltage-sensitive dyes |
| Zusammenfassung | The electrical activity of adult mouse and rat hearts has been analyzed extensively, often as a prerequisite for genetic engineering studies or for the development of rodent models of human diseases. Some aspects of the initiation and conduction of the cardiac action potential in rodents closely resemble those in large mammals. However, rodents have a much higher heart rate and their ventricular action potential is triangular and very short. As a consequence, an interpretation of the electrocardiogram in the mouse and rat remains difficult and controversial. In this study, optical mapping techniques have been applied to an in vitro left ventricular adult rat preparation to obtain patterns of conduction and action potential duration measurements from the epicardial surface. This information has been combined with previously published mathematical models of the rat ventricular myocyte to develop a bidomain model for action potential propagation and electrogram formation in the rat left ventricle. Important insights into the basis for the repolarization waveform in the ventricular electrogram of the adult rat have been obtained. Notably, our model demonstrated that the biphasic shape of the rat ventricular repolarization wave can be explained in terms of the transmural and apex-to-base gradients in action potential duration that exist in the rat left ventricle. |
Zitierung
Weber dos Santos, R., Nygren, A., Campos, F. O., Koch, H., & Giles, W. (2009). Experimental and theoretical ventricular electrograms and their relation to electrophysiological gradients in the adult rat heart. American Journal of Physiology: Heart and Circulatory Physiology, 297(4), H1521–H1534. https://doi.org/10.1152/ajpheart.01066.2008