| Zugriffsnummer | 23423 |
| Dokumenttyp | Zeitschriftenartikel |
| Peer Review | unbekannt |
| Sprache | Englisch |
| Titel | Nonlinear reconstruction of absorption and fluorescence contrast from measured diffuse transmittance and reflectance of a compressed-breast-simulating phantom |
| Autor(in); Institution |
Ziegler, R.; Philips Research Europe-Hamburg, Hamburg, GERMANY
Nielsen, T.; Philips Research Europe-Hamburg, Hamburg, GERMANY
Koehler, T.; Philips Research Europe-Hamburg, Hamburg, GERMANY
Grosenick, Dirk; 8.3, Biomedizinische Optik, PTB-Berlin
Steinkellner, Oliver; 8.3, Biomedizinische Optik, PTB-Berlin
Hagen, Axel; 8.3, Biomedizinische Optik, PTB-Berlin
Macdonald, Rainer; 8.3, Biomedizinische Optik, PTB-Berlin
Rinneberg, Herbert; PTB-Berlin, retired staff
|
| Quelle/Jahr | Applied Optics: 48 (2009), 24, 4651 - 4662 |
| ISSN | 0003-6935 (PRINT) ; 1539-4522 (ONLINE) |
| DOI | |
| URL | |
| Verlag | Washington, DC: Optical Society of America, OSA |
| Klassifikationscode | OCIS: 100.3010 ; OCIS: 170.0110 ; OCIS: 170.3830 ; OCIS: 170.7050 |
| Freie Schlagworte | diffuse optical imaging ; optical tomography ; nonlinear reconstruction |
| Zusammenfassung | We report on the nonlinear reconstruction of local absorption and fluorescence contrast in tissuelike scattering media from measured time-domain diffuse reflectance and transmittance of laser as well as laser-excited fluorescence radiation. Measurements were taken at selected source–detector offsets using slablike diffusely scattering and fluorescent phantoms containing fluorescent heterogeneities. Such measurements simulate in vivo data that would be obtained employing a scanning, time-domain fluorescence mammograph, where the breast is gently compressed between two parallel glass plates, and source and detector optical fibers scan synchronously at various source–detector offsets, allowing the recording of laser and fluorescence mammograms. The diffusion equations modeling the propagation of the laser and fluorescence radiation were solved in frequency domain by the finite element method simultaneously for several modulation frequencies using Fourier transformation and preprocessed experimental data. To reconstruct the concentration of the fluorescent contrast agent, the Born approximation including higher-order reconstructed photon densities at the excitation wavelength was used. Axial resolution was determined that can be achieved by various detection schemes. We show that remission measurements increase the depth resolution significantly. Online auch erschienen in: Virtual Journal for Biomedical Optics 4(2009),10 |
Zitierung
Ziegler, R., Nielsen, T., Koehler, T., Grosenick, D., Steinkellner, O., Hagen, A., Macdonald, R., & Rinneberg, H. (2009). Nonlinear reconstruction of absorption and fluorescence contrast from measured diffuse transmittance and reflectance of a compressed-breast-simulating phantom. Applied Optics, 48(24), 4651–4662. https://doi.org/10.1364/ao.48.004651