| Zugriffsnummer | 22390 |
| Dokumenttyp | Zeitschriftenartikel |
| Peer Review | unbekannt |
| Sprache | Englisch |
| Titel | Towards noninvasive molecular fluorescence imaging of the human brain |
| Autor(in); Institution |
Steinbrink, Jens; 8.3, Biomedizinische Optik, PTB-Berlin; Institute of Biocybernetics and Biomedical Engineering, Warsaw, POLAND
Liebert, Adam; Institute of Biocybernetics and Biomedical Engineering, Warsaw, POLAND
Wabnitz, Heidrun; 8.3, Biomedizinische Optik, PTB-Berlin
Macdonald, Rainer; 8.3, Biomedizinische Optik, PTB-Berlin
Obrig, Hellmuth; Clinic of Neurology, Charité – Universitätsmedizin Berlin, GERMANY
Wunder, A.; Clinic of Neurology, Charité – Universitätsmedizin Berlin, GERMANY
Bourayou, R.; Clinic of Neurology, Charité – Universitätsmedizin Berlin, GERMANY
Betz, T.; Clinic of Neurology, Charité – Universitätsmedizin Berlin, GERMANY
Klohs, J.; Clinic of Neurology, Charité – Universitätsmedizin Berlin, GERMANY
Lindauer, U.; Clinic of Neurology, Charité – Universitätsmedizin Berlin, GERMANY
Dirnagl, U.; Clinic of Neurology, Charité – Universitätsmedizin Berlin, GERMANY
Villringer, A.; Clinic of Neurology, Charité – Universitätsmedizin Berlin, GERMANY
|
| Quelle/Jahr | Neurodegenerative Diseases: 5 (2008), 5, 296 - 303 |
| ISSN | 1660-2854 (PRINT) ; 1660-2862 (ONLINE) |
| DOI | |
| Verlag | Basel: Karger |
| Freie Schlagworte | Molecular imaging ; Fluorescence ; Brain imaging |
| Zusammenfassung | Fluorescence molecular brain imaging is a new modality allowing the detection of specific contrast agents down to very low concentration ranges (picomolar) in disease models. Here we demonstrate a first noninvasive application of fluorescence imaging in the human brain, where concentrations down to about 100 n M of a nonspecific dye were detected. We argue that due to its high sensitivity, optical molecular imaging of the brain is feasible, which – together with its bedside applicability – makes it a promising technique for use in patients. |
Zitierung
Steinbrink, J., Liebert, A., Wabnitz, H., Macdonald, R., Obrig, H., Wunder, A., Bourayou, R., Betz, T., Klohs, J., Lindauer, U., Dirnagl, U., & Villringer, A. (2008). Towards noninvasive molecular fluorescence imaging of the human brain. Neurodegenerative Diseases, 5(5), 296–303. https://doi.org/10.1159/000135614