| Zugriffsnummer | 22386 |
| Dokumenttyp | Zeitschriftenartikel |
| Peer Review | mit Peer Review |
| Sprache | Englisch |
| Titel | Monte Carlo algorithm for efficient simulation of time-resolved fluorescence in layered turbid media |
| Autor(in); Institution |
Liebert, Adam; Institute of Biocybernetics and Biomedical Engineering, Warsaw, POLAND
Wabnitz, Heidrun; 8.3, Biomedizinische Optik, PTB-Berlin
Zolek, Norbert; Institute of Biocybernetics and Biomedical Engineering, Warsaw, POLAND
Macdonald, Rainer; 8.3, Biomedizinische Optik, PTB-Berlin
|
| Quelle/Jahr | Optics Express: 16 (2008), 17, 13188 - 13202 |
| Availability | [online only] |
| ISSN | 1094-4087 |
| DOI | |
| Verlag | Washington, DC: Optical Society of America |
| Klassifikationscode | OCIS: 170.3660 ; OCIS: 170.6280 |
| Freie Schlagworte | Light propagation in tissues ; Spectroscopy, fluorescence and luminescence |
| Zusammenfassung | We present an efficient Monte Carlo algorithm for simulation of timeresolved fluorescence in a layered turbid medium. It is based on the propagation of excitation and fluorescence photon bundles and the assumption of equal reduced scattering coefficients at the excitation and emission wavelengths. In addition to distributions of times of arrival of fluorescence photons at the detector, 3-D spatial generation probabilities were calculated. The algorithm was validated by comparison with the analytical solution of the diffusion equation for time-resolved fluorescence from a homogeneous semi-infinite turbid medium. It was applied to a two-layered model mimicking intra- and extracerebral compartments of the adult human head. |
| Kostenfreier Zugang | Open Access Gold |