| Zugriffsnummer | 21728 |
| Dokumenttyp | Zeitschriftenartikel |
| Sprache | Englisch |
| Titel | Reference measurement procedure for Δ9-tetrahydrocannabinol in serum |
| Autor(in); Institution |
Lott, Susanne; 3.1, Metrologie in der Chemie, PTB-Braunschweig; University of Heidelberg, Institute of Legal Medicine and Traffic Medicine, Heidelberg, GERMANY
Henrion, André; 3.1, Metrologie in der Chemie, PTB-Braunschweig
Malz, F.; Federal Institute for Material Research and Testing (BAM), Berlin, GERMANY
Kessler, A.; University of Bonn, Institute of Clinical Chemistry and Pharmacology, Bonn, GERMANY
Güttler, Bernd; 3.1, Metrologie in der Chemie, PTB-Braunschweig
Aderjan, R.; University of Heidelberg, Institute of Legal Medicine and Traffic Medicine, Heidelberg, GERMANY
|
| Quelle/Jahr | Analytical and Bioanalytical Chemistry: 391 (2008), 1003 - 1010 |
| ISSN | 1618-2642 (PRINT) ; 1618-2650 (ONLINE) |
| DOI | |
| Verlag | Berlin [u.a.]: Springer |
| Freie Schlagworte | THC ; Uncertainty of measurement ; GUM ; Threshold value ; reference material ; primary method ; quantitative NMR |
| Zusammenfassung | An isotope dilution gas chromatography/mass spectrometry (ID-GC/MS) reference measurement procedure for Δ9-tetrahydrocannabinol (THC) in serum was developed and validated. the method complies with the concept of a ratio primary reference measurement procedure. The uncertainty was determined for two concentrations of THC in serum (1 ng/mL and 2.4 ng/mL). The calculation procedrue is based on the Guide to the Expression of Uncertainty in Measurement (GUM). The relative expanded uncertainty was found to be less than 2% for both concentration levels, corresponding to a 95 % confidence interval. for the reference method, it was shown that the measurement of THC within the concentration range covered by the current threshold values is very accurate. The method has the potential to provide traceability for the methods used in practical forensics. |
