| Zugriffsnummer | 20134 |
| Dokumenttyp | Zeitschriftenartikel |
| Sprache | Englisch |
| Titel | Abnormal hippocampal neurochemistry in smokers : Evidence from proton magnetic resonance spectroscopy at 3 T |
| Autor(in); Institution |
Gallinat, J.; Charité Universtitätsmedizin Berlin, Campus Benjamin Franklin, Abteilung Psychiatrie und Psychotherapie, Berlin, GERMANY
Lang, U.; Department of Physiology, University of Tuebingen, GERMANY
Jacobsen, L.; Departments of Psychiatry and Pediatrics, Yale University School of Medicine, New Haven, USA
Bajbouj, M.; Charité Universtitätsmedizin Berlin, Campus Benjamin Franklin, Abteilung Psychiatrie und Psychotherapie, Berlin, GERMANY
Kalus, P.; Charité Universtitätsmedizin Berlin, Campus Benjamin Franklin, Abteilung Psychiatrie und Psychotherapie, Berlin, GERMANY
Haebler, D. von; Charité Universtitätsmedizin Berlin, Campus Benjamin Franklin, Abteilung Psychiatrie und Psychotherapie, Berlin, GERMANY
Seifert, Frank; 8.1, Medizinische Messtechnik, PTB-Berlin
Schubert, Florian; 8.1, Medizinische Messtechnik, PTB-Berlin
|
| Quelle/Jahr | Journal of Clinical Psychopharmacology: 27 (2007), 1, 80 - 84 |
| ISSN | 0271-0749 (PRINT) ; 1533-712X (ONLINE) |
| DOI | |
| Verlag | Baltimore, Md.: Williams & Wilkins |
| Zusammenfassung | Objective: In animals, nicotine, the primary psychoactive constituent of tobacco smoke, reduces neurogenesis and increases cell loss in both hippocampus and cortex. Accordingly, tobacco smoking has been linked to reduced performance on cognitive paradigms requiring attention and working memory in humans. However, few prior studies have tested for evidence of structural brain alterations in human tobacco smokers. In this study, proton magnetic resonance pectroscopy was used to assess the effects of chronic smoking on neuronal integrity of the hippocampus and anterior cingulate cortex (ACC). Methods: Absolute concentrations of N-acetylaspartate, total choline (tCho), and total creatine were measured in the left hippocampus and ACC in 13 chronic tobacco smokers and 13 nonsmokers matched forage, sex, and education. Results: The N-acetylaspartate concentration was significantly reduced in smokers relative to nonsmokers in the left hippocampus but not in the ACC. There were no group differences in the tCho and total creatine concentrations in either voxel. However, ACCtCho concentration was positively correlated with magnitude of lifetime exposure to tobacco smoke (pack-years). Conclusion: The results are consistent with prior observations of hippocampal neuronal damage in rodents receiving nicotine and working memory deficits in human tobacco smokers. The positive relationship between tCho and lifetime tobacco exposure suggests that a component of tobacco smoke, presumably nicotine, may increase cortical membrane turnover or modify cell density. Together, these results add to growing evidence that nicotine exerts neurotoxic effects in human brain, although an a priori nature of the findings cannot be ruled out. |
Zitierung
Gallinat, J., Lang, U., Jacobsen, L., Bajbouj, M., Kalus, P., Haebler, D. V., Seifert, F., & Schubert, F. (2007). Abnormal hippocampal neurochemistry in smokers : Evidence from proton magnetic resonance spectroscopy at 3 T. Journal of Clinical Psychopharmacology, 27(1), 80–84. https://doi.org/10.1097/jcp.0b013e31802dffde