| Zugriffsnummer | 19922 |
| Dokumenttyp | Konferenzartikel |
| Sprache | Englisch |
| Titel | Brain glutamate concentration by MRS at 3 T in tobacco smoking: comparison of smokers, former smokers and never-smokers [poster] |
| Autor(in); Institution |
Schubert, Frank; 8.1, Medizinische Messtechnik, PTB-Berlin
Seifert, Frank; 8.1, Medizinische Messtechnik, PTB-Berlin
Gallinat, J.; Charité Medicine Berlin, Department of Psychiatry and Psychotherapy, D-10559 Berlin, GERMANY
|
| Quelle/Jahr | Book of Abstracts ESMRMB 2006 23rd Annual Scientific Meeting:(2006) |
| Availability | [CD-ROM] |
| Konferenzangaben | European Society for Magnetic Resonance in Medicine and Biology, 23rd Annual Scientific Meeting (ESMRMB), Warsaw, 21-23, September, 2006, Poland |
| Zusammenfassung | WHO identifies tobacco smoking as the single largest preventable cause of disease in developed countries. Dysfunction of the brain reward system has been implicated in chronic cigarette consumption. The interaction of dopamine and glutamate appears crucial for dysfunctional reward processing. Thus, altered glutamatergic neurotransmission may result in dysfunctional control over drug seeking in long term addiction In the present study, glutamate concentrations in frontal and hippocampal regions were compared in smokers, former smokers and non-smokers using a dedicated 1H-MRS procedure at 3 tesla. Thirteen smokers, 9 former smokers and 16 never-smokers matched for age, gender, education and alcohol consumption were examined. MR spectra were acquired on a 3-tesla-scanner (MEDSPEC 30/100, Bruker Medical) using PRESS optimized for glutamate determination from brain voxels including the anterior cingulate gyrus (AC) and the left hippocampus (HC). The comparison of the three groups revealed no significant differences in the voxel volume fractions of CSF, gray matter and white matter. Analysis of variance (MANOVA) showed no significant influence of the factor `smoking status` (never-smokers, former smokers, smokers) on glutamate concentrations in the HC or AC. Daily cigarette consumption, lifetime tobacco exposure (pack-years) and age of smoking onset did not correlate significantly with glutamate concentrations in hippocampus nor cingulate. Although these results do not rule out glutamatergic dysfunctions they do not support a crucial role of cingulate or hippocampal glutamate as measured by 1H-MRS in chronic tobacco consumption. |
Zitierung
Schubert, F., Seifert, F., & Gallinat, J. (2006). Brain glutamate concentration by MRS at 3 T in tobacco smoking: comparison of smokers, former smokers and never-smokers [poster]. European Society for Magnetic Resonance in Medicine and Biology, 23rd Annual Scientific Meeting (ESMRMB), Warsaw, 21-23, September, 2006, Poland.