| Zugriffsnummer | 19919 |
| Dokumenttyp | Zeitschriftenartikel |
| Sprache | Englisch |
| Titel | Association between cerebral glutamate and human behaviour: the sensation seeking personality trait |
| Autor(in); Institution |
Gallinat, J.; Clinic for Psychiatry and Psychotherapy, Charité University Medicine, Campus Mitte, Berlin, GERMANY
Kunz, D.; Clinic for Psychiatry and Psychotherapy, Ludwig-Maximilians-Universität, München, GERMANY
Lang, U.E.; Department of Psychiatry and Psychotherapy, University Hospital of Dresden, GERMANY
Neu, P.; Department of Psychiatry and Psychotherapy, Charité University Medicine Berlin, Campus Benjamin Franklin, GERMANY
Kassim, N.; Clinic for Psychiatry and Psychotherapy, Charité University Medicine, Campus Mitte, Berlin, GERMANY
Kienast, T.; Clinic for Psychiatry and Psychotherapy, Charité University Medicine, Campus Mitte, Berlin, GERMANY
Seifert, Frank; 8.1, Medizinische Messtechnik, PTB-Berlin
Schubert, Florian; 8.1, Medizinische Messtechnik, PTB-Berlin
Bajbouj, M.; Department of Psychiatry and Psychotherapy, Charité UnivCampus Benjamin Franklin, GERMANY
|
| Quelle/Jahr | NeuroImage: 34 (2007), 2, 671 - 678 |
| ISSN | 1053-8119 |
| DOI | |
| Verlag | Amsterdam: Elsevier |
| Freie Schlagworte | Magnetic resonance spectroscopy ; Glutamate ; Anterior ; cingulate cortex ; Hippocampus ; Personality traits ; Sensation seeking |
| Zusammenfassung | Introduction: Brain imaging studies have linked the anterior cingulate cortex (ACC) to motivation, drive, and personality traits like novelty and sensation seeking. Animal studies have shown glutamatergic neurotransmission to be important in ACC function as well as motivated behaviour. However, the role of glutamate in related personality traits like sensation seeking has not been investigated in humans. Methods: The associations between sensation seeking personality scores and absolute glutamate concentrations in the ACC and the hippocampal region measured by 3-Tesla proton magnetic resonance spectroscopy (1H-MRS) were investigated. Results: ACC glutamate concentration was negatively correlated with the sensation seeking sum score and the experience seeking subscore. A weak negative correlation was also observed between the hippocampal glutamate and the sensation seeking sum score. The reexamination of the glutamate concentration after 4 weeks revealed a similar relationship with sensation seeking. Discussion: Although preliminary, the results are in line with the key role of the ACC for motivation and executive control and with the impact of glutamate on novelty related behaviour observed in animal experiments. The role of the hippocampus for novelty processing is discussed. Glutamate measurement with 1H-MRS may facilitate the understanding of biological underpinnings of personality traits and psychiatric diseases associated with dysfunctions in motivation and drive. |
Zitierung
Gallinat, J., Kunz, D., Lang, U., Neu, P., Kassim, N., Kienast, T., Seifert, F., Schubert, F., & Bajbouj, M. (2007). Association between cerebral glutamate and human behaviour: the sensation seeking personality trait. NeuroImage, 34(2), 671–678. https://doi.org/10.1016/j.neuroimage.2006.10.004