| Zugriffsnummer | 19327 |
| Dokumenttyp | Konferenzartikel |
| Sprache | Englisch |
| Titel | Nanoparticle-distribution after magnetic drug targeting |
| Autor(in); Institution |
Alexiou, Christoph; University Erlangen-Nürnberg, Department of otorhinolaryngology, Head and Neck Surgery, Erlangen, GERMANY
Jurgons, Roland; University Erlangen-Nürnberg, Department of otorhinolaryngology, Head and Neck Surgery, Erlangen, GERMANY
Seliger, Christian; University Erlangen-Nürnberg, Department of otorhinolaryngology, Head and Neck Surgery, Erlangen, GERMANY
Brunke, O.; Universität Dresden, Lehrstuhl für Magnetofluiddynamik, Dresden, GERMANY
Odenbach, S.; Universität Dresden, Lehrstuhl für Magnetofluiddynamik, Dresden, GERMANY
Hess, A.; University Erlangen-Nürnberg, Department of clinical pharmacology and toxicology, Erlangen, GERMANY
Wiekhorst, Frank; 8.2, Biosignale, PTB-Berlin
Eberbeck, Dietmar; 8.2, Biosignale, PTB-Berlin
Trahms, Lutz; 8.2, Biosignale, PTB-Berlin
Iro, H.; University Erlangen-Nürnberg, Department of otorhinolaryngology, Head and Neck Surgery, Erlangen, GERMANY
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| Quelle/Jahr | Recent Development in Ferrofluid Research, EUROMECH Colloquium 470:(2006), 14 - 15 |
| Konferenzangaben | EUROMECH Colloquium 470, Dresden, 27, February - 01, March, 2006, Germany |
| Freie Schlagworte | magnetic nanoparticles ; magnetic drug targeting ; tumor therapy |
| Zusammenfassung | In medicine magnetic nanoparticles can be used in vivo as MR-imaging contrast agents. A new approach in regional cancer therapy is Magnetic Drug Targeting (MDT). Functionalised magnetic nanoparticles, bound to mitoxantrone, were given intraarterially and attracted in the tumor region with an external magnetic field (1.7 Tesla). Figure 1 shows a electromicroscopic picture of nanoparticles, which were used in our experiments. Using this delivery system we could achieve total tumor remissions without negative side effects in tumor bearing rabbits by the use of only 20 % and 50 % of the regular systemic chemotherapeutic dosage. Measurements of radioactive 59Fe-nanoparticles showed 114 times more activity in the tumor region after Magnetic Drug Targeting compared to the control without magnetic field. HPLC-analysis of the chemotherapeutic agent after MDT revealed a 75 times higher concentration of the administered dose in the tumor region compared to the regular systemic administration. In the present study the distribution of the particles after MDT was investigated by non invasive common imaging techniques and by spatially resolved magnetorelaxometry. |
