| Zugriffsnummer | 17643 |
| Dokumenttyp | Zeitschriftenartikel |
| Sprache | Englisch |
| Titel | Time-domain scanning optical mammography: I. Recording and assessment of mammograms of 154 patients |
| Autor(in); Institution |
Grosenick, Dirk; 8.3, Biomedizinische Optik, PTB-Berlin
Moesta, K. Thomas; Department of Surgery and Surgical Oncology, Robert-Rössle-Hospital, Charite, Campus Buch, Berlin, GERMANY
Möller, Michael; 8.3, Biomedizinische Optik, PTB-Berlin
Mucke, Jörg; Department of Surgery and Surgical Oncology, Robert-Rössle-Hospital, Charite, Campus Buch, Berlin, GERMANY
Wabnitz, Heidrun; 8.3, Biomedizinische Optik, PTB-Berlin
Gebauer, Bernd; Department of Radiolgy, Charite, Campus Virchow-Klinikum, Berlin, GERMANY
Stroszczynski, Christian; Department of Radiolgy, Charite, Campus Virchow-Klinikum, Berlin, GERMANY
Wassermann, Bernhard; 8.3, Biomedizinische Optik, PTB-Berlin
Schlag, Peter M.; Department of Surgery and Surgical Oncology, Robert-Rössle-Hospital, Charite, Campus Buch, Berlin, GERMANY
Rinneberg, Herbert; 8, Medizinphysik und metrologische Informationstechnik, PTB-Berlin
|
| Quelle/Jahr | Physics in Medicine and Biology: 50 (2005), 11, 2429 - 2449 |
| ISSN | 0031-9155 |
| DOI | |
| Verlag | Bristol: IOP Publ. |
| Freie Schlagworte | Optical mammography ; Time-resolved imaging ; Tissue optical properties |
| Zusammenfassung | Using a triple wavelength (670 nm, 785 nm, 843/884nm) scanning laser pulse mammograph we recorded craniocaudal and mediolateral projection optical mammograms of 154 patients, suspected to have breast cancer. From distributions of times of flight (DTOFs) of photons recorded at typically 1000-2000 scan positions, optical mammograms were derived displaying (inverse) photon counts in selected time windows, absorption and reduced scattering coefficients or total haemoglobin concentration and blood oxygen saturation. Optical mammograms were analysed by comparing them with x-ray and MR mammograms, including results of histopathology, attributing a subjective visibility score to each tumour assessed. Out of 102 histologically confirmed tumours, 72 tumours were detected retrospectively in both optical projection mammograms, in additional 20 cases in one projection only, whereas 10 tumours were not detectable in any projection. Tumour contrast and contrast-to-noise ratios of mammograms of the same breast, but derived from measured DTOFs by various methods were quantitatively compared. On average, inverse photon counts in selected time windows, including total photon counts, provide highest tumour contrast and contrast-to-noise ratios. Based on the results of the present study we developed a multi-wavelength, multi-projection scanning time domain optical mammograph with improved spectral and spatial (angular) sampling, that allows to record entire mammograms simultaneously at various offsets between the transmitting fibre and receiving fibre bundle and provide first results for illustration. |
Zitierung
Grosenick, D., Moesta, K. T., Möller, M., Mucke, J., Wabnitz, H., Gebauer, B., Stroszczynski, C., Wassermann, B., Schlag, P. M., & Rinneberg, H. (2005). Time-domain scanning optical mammography: I. Recording and assessment of mammograms of 154 patients. Physics in Medicine and Biology, 50(11), 2429–2449. https://doi.org/10.1088/0031-9155/50/11/001